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Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates
- Source :
- Glycoconjugate Journal. 32:127-140
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani. Graphical Abstract Click Inspired Synthesis of Antileishmanial Triazolyl O-Benzylquercetin Glycoconjugates.
- Subjects :
- Glycoconjugate
Stereochemistry
Drug Evaluation, Preclinical
Leishmania donovani
Biochemistry
Cell Line
Mice
chemistry.chemical_compound
Animals
Organic chemistry
Amastigote
Molecular Biology
Dichloromethane
chemistry.chemical_classification
biology
Macrophages
Regioselectivity
Cell Biology
Triazoles
biology.organism_classification
Trypanocidal Agents
Cycloaddition
chemistry
Click chemistry
Click Chemistry
Quercetin
Subjects
Details
- ISSN :
- 15734986 and 02820080
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Glycoconjugate Journal
- Accession number :
- edsair.doi.dedup.....d38ed9fdb64c71fd77f637b5b08f42a7