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Gastrointestinal hormones in regulation of memory
- Source :
- Peptides. 102
- Publication Year :
- 2017
-
Abstract
- The connection between the gastrointestinal hormones and the brain has been established many years ago. This relation is termed the gut-brain axis (GBA). The GBA is a bidirectional communication which not only regulates gastrointestinal homeostasis but is also linked with higher emotional and cognitive functions. Hypothalamus plays a critical role in the regulation of energy metabolism, nutrient partitioning and control of feeding behaviors. Various gut hormones are released inside the gastrointestinal tract on food intake. These hormones act peripherally and influence the different responses of the tissues to the food intake, but do also have effects on the brain. The hypothalamus, in turn, integrates visceral function with limbic system structures such as hippocampus, amygdala, and cerebral cortex. The hippocampus has been known for its involvement in the cognitive function and the modulation of synaptic plasticity. This review aims to establish the role of various gut hormones in learning and memory, through the interaction of various receptors in the hippocampus. Understanding their role in memory can also aid in finding novel therapeutic strategies for the treatment of the neurological disorders associated with memory dysfunctions.
- Subjects :
- 0301 basic medicine
Physiology
Gut–brain axis
Hypothalamus
Hippocampus
Biology
Biochemistry
Amygdala
Gastrointestinal Hormones
03 medical and health sciences
Cellular and Molecular Neuroscience
Eating
0302 clinical medicine
Endocrinology
Limbic system
Cognition
Memory
Neuroplasticity
medicine
Humans
Learning
Neuronal Plasticity
Gastrointestinal Tract
030104 developmental biology
medicine.anatomical_structure
Ghrelin
Neuroscience
030217 neurology & neurosurgery
Hormone
Subjects
Details
- ISSN :
- 18735169
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....d380f083b8a75fcc51c07740e3825d67