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Choroidal Vascularity Index in Different Cohorts of Dry Age-Related Macular Degeneration
- Source :
- Translational Vision Science & Technology
- Publication Year :
- 2021
- Publisher :
- The Association for Research in Vision and Ophthalmology, 2021.
-
Abstract
- Purpose The purpose of this study was to investigate the choroidal luminal and interstitial stromal alterations using choroidal vascularity index (CVI) among different cohorts of dry age-related macular degeneration (dAMD) compared to healthy subjects. Methods Four distinct cohorts were collected: three different cohorts of patients with dAMD (i.e. drusen, reticular pseudodrusen [RPD], and geographic atrophy [GA]) and an age-matched cohort of healthy subjects (controls). CVI (the ratio between the luminal choroidal area [LCA] and the total choroidal area [TCA]) was calculated in the subfoveal 1000 µm area. Results One hundred twenty eyes (from 120 patients) were included (30 eyes in each cohort). The mean age was 76.6 ± 7.1 years. No statistical differences were disclosed in terms of age, axial length, and central macular thickness among study groups. TCA showed a different distribution among the four cohorts (P = 0.003), mainly due to the LCA changes (P = 0.001). Interestingly, CVI showed a different distribution among the four cohorts (P < 0.001). RPD showed a lower CVI in comparison to controls (P = 0.040), whereas GA showed a lower CVI in comparison to drusen, RPD, and controls (P = 0.001, P = 0.046, and P < 0.001, respectively). Conclusions Different cohorts of dAMD are characterized by different impairments of the choroidal vascular and stromal components, reflecting different degrees of AMD severity. Translational Relevance CVI provides insights for better understanding the pathogenesis of AMD.
- Subjects :
- medicine.medical_specialty
Biomedical Engineering
Drusen
Article
Macular Degeneration
Vascularity
Ophthalmology
Geographic Atrophy
Medicine
Humans
Fluorescein Angiography
Dry age-related macular degeneration
Aged
Aged, 80 and over
age-related macular degeneration (AMD)
geographic atrophy (GA)
medicine.diagnostic_test
business.industry
Choroid
CVI
Macular degeneration
choroidal vascularity index
medicine.disease
Fluorescein angiography
eye diseases
Geographic atrophy
reticular pseudodrusen (RPD)
Cohort
sense organs
medicine.symptom
business
Tomography, Optical Coherence
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 21642591
- Volume :
- 10
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Translational Vision Science & Technology
- Accession number :
- edsair.doi.dedup.....d37c24961aff03bd9cbba0f36ce7e685