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Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso
- Source :
- Malaria Journal, Malaria Journal, Vol 11, Iss 1, p 79 (2012)
- Publication Year :
- 2012
- Publisher :
- BioMed Central, 2012.
-
Abstract
- Background Patient immune status is thought to affect the efficacy of anti-malarial chemotherapy. This is a subject of some importance, since evidence of immunity-related interactions may influence our use of chemotherapy in populations with drug resistance, as well as assessment of the value of suboptimal vaccines. The study aim was to investigate relationship between antibodies and anti-malarial drug treatment outcomes. Methods Some 248 children aged 0.5 and 15 years were recruited prior to the high malaria transmission season. Venous blood (5 ml) was obtained from each child to measure antibody levels to selected malaria antigens, using ELISA. Blood smears were also performed to assess drug efficacy and malaria infection prevalence. Children were actively followed up to record clinical malaria cases. Results IgG levels to MSP3 were always higher in the successfully treated group than in the group with treatment failure. The same observation was made for GLURP but the reverse observation was noticed for MSP1-19. Cytophilic and non-cytophilic antibodies were significantly associated with protection against all three antigens, except for IgG4 to MSP1-19 and GLURP. Conclusion Acquired anti-malarial antibodies may play an important role in the efficacy of anti-malarial drugs in younger children more susceptible to the disease.
- Subjects :
- Male
medicine.medical_treatment
Protozoan Proteins
Sulphadoxine/pyrimethamine
Antibodies, Protozoan
Drug resistance
Chloroquine
Malaria, Falciparum
Child
biology
Malaria vaccine
Drug Combinations
Infectious Diseases
Pyrimethamine
Treatment Outcome
Child, Preschool
Drug Therapy, Combination
Female
medicine.drug
lcsh:Arctic medicine. Tropical medicine
Adolescent
lcsh:RC955-962
Sulfadoxine
Plasmodium falciparum
Antibodies
lcsh:Infectious and parasitic diseases
Antimalarials
parasitic diseases
Burkina Faso
Malaria Vaccines
medicine
Humans
lcsh:RC109-216
GLURP
Chemotherapy
business.industry
MSP3
Research
Infant
biology.organism_classification
Parasitology
Immunoglobulin G
Immunology
MSP1-19
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 14752875
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Malaria Journal
- Accession number :
- edsair.doi.dedup.....d375f9689913a28cb9ae7106ca9ca527