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The International Testicular Cancer Linkage Consortium: A Clinicopathologic Descriptive Analysis of 461 Familial Malignant Testicular Germ Cell Tumor Kindred
- Source :
- Urologic Oncology-Seminars and Original Investigations, 28(5), 492-499. ELSEVIER SCIENCE INC
- Publication Year :
- 2009
-
Abstract
- Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with >= 2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism. TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families. Conclusions: Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial eases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation. Published by Elsevier Inc.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Testicular neoplasms
Epidemiology
Urology
Cousin
Population
Testicular Germ Cell Tumor
Hernia, Inguinal
Clinicopathologic characteristics
Article
Familial
Internal medicine
Cryptorchidism
medicine
Humans
ANTICIPATION
education
Testicular cancer
POPULATION
Gynecology
FATHER
education.field_of_study
business.industry
TESTIS
Family aggregation
Cancer
Seminoma
Neoplasms, Germ Cell and Embryonal
medicine.disease
SUSCEPTIBILITY GENES
Malignant Testicular Germ Cell Tumor
OF-THE-LITERATURE
RISK-FACTORS
EXPERIENCE
business
Subjects
Details
- Language :
- English
- ISSN :
- 10781439
- Database :
- OpenAIRE
- Journal :
- Urologic Oncology-Seminars and Original Investigations, 28(5), 492-499. ELSEVIER SCIENCE INC
- Accession number :
- edsair.doi.dedup.....d36fcd9b75718530ffe4df7e8af40e15