Back to Search
Start Over
Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis
- Source :
- Journal of Translational Medicine, Vol 10, Iss 1, p 106 (2012), Journal of Translational Medicine
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Background Zinc-alpha2-glycoprotein (AZGP1, ZAG) was recently demonstrated to be an important factor in tumor carcinogenesis. However, AZGP1 expression in hepatocellular carcinoma (HCC) and its significance remain largely unknown. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to determine mRNA level of AZGP1 in 20 paired fresh HCC tissues. Clinical and pathological data of 246 HCC patients were collected. Tissue-microarray-based immunohistochemistry (IHC) was performed to examine AZGP1 expression in HCC samples. Relationship between AZGP1 expression and clinicopathological features was analyzed by Chi-square test, Kaplan-Meier analysis and Cox proportional hazards regression model. Results AZGP1 expression was significantly lower in 80.0% (16/20) of tumorous tissues than that in the corresponding adjacent nontumorous liver tissues (P P P = 0.013), liver cirrhosis (P = 0.002) and tumor differentiation (P = 0.025). Moreover, HCC patients with high AZGP1 expression survived longer, with better overall survival (P = 0.006) and disease-free survival (P = 0.025). In addition, low AZGP1 expression associated with worse relapse-free survival (P = 0.046) and distant metastatic progression-free survival (P = 0.036). Conclusion AZGP1 was downregulated in HCC and could be served as a promising prognostic marker for HCC patients.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Carcinoma, Hepatocellular
Hepatocellular carcinoma
Down-Regulation
lcsh:Medicine
AZGP1
Biology
Real-Time Polymerase Chain Reaction
Zn-Alpha-2-Glycoprotein
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Metastasis
Downregulation and upregulation
Recurrence
medicine
Carcinoma
Humans
RNA, Messenger
DNA Primers
Medicine(all)
Base Sequence
Biochemistry, Genetics and Molecular Biology(all)
Research
Liver Neoplasms
lcsh:R
Seminal Plasma Proteins
General Medicine
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
digestive system diseases
Real-time polymerase chain reaction
Tissue Array Analysis
Cancer research
Female
Carcinogenesis
Subjects
Details
- ISSN :
- 14795876
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Translational Medicine
- Accession number :
- edsair.doi.dedup.....d3677fe38521d4e86cf438126809ec1c