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Comparison between Dexmedetomidine and Remifentanil for Controlled Hypotension and Recovery in Endoscopic Sinus Surgery
- Source :
- Annals of Otology, Rhinology & Laryngology. 122:421-426
- Publication Year :
- 2013
- Publisher :
- SAGE Publications, 2013.
-
Abstract
- Objectives:We compared the efficacy of dexmedetomidine and remifentanil hydrochloride in intraoperative field conditions and recovery during endoscopic sinus surgery.Methods:Sixty-six patients (American Society of Anesthesiologists physical status I and II) scheduled for elective endoscopic sinus surgery were enrolled in this prospective, double-blinded, randomized study. The patients were randomly assigned to two groups. Propofol, 2 to 2.5 mg/kg, was administered to both groups to induce anesthesia, which was maintained with desflurane. One group received dexmedetomidine 1 μg/kg over 10 minutes at anesthesia induction, followed by 0.4 to 0.8 μg/kg per hour infusion during maintenance, whereas the other group received remifentanil 1 μg/kg over 1 minute at anesthesia induction, followed by 0.2 to 0.4 μg/kg per minute infusion during maintenance. Surgical conditions, hemodynamic parameters, intraoperative blood loss, time to extubation, sedation, and pain in the postanesthesia care unit (PACU) were recorded.Results:There were no significant differences between the two groups with respect to surgical field conditions, blood loss, or extubation time. The sedation score (Modified Observer's Assessment of Alertness/Sedation) in the PACU was significantly lower in the dexmedetomidine group than in the remifentanil group (p < 0.001). No differences were found in total blood loss, surgical field conditions, hemodynamic parameters, time to extubation, or pain in the PACU when the two groups were compared (p > 0.05).Conclusions:Although remifentanil and dexmedetomidine both enabled hypotensive anesthesia and good intraoperative fields for endoscopic sinus surgery, recovery was faster with remifentanil than with dexmedetomidine in the immediate postoperative period.
- Subjects :
- Adult
Male
Natural Orifice Endoscopic Surgery
medicine.medical_specialty
Sedation
Nasal Surgical Procedures
Remifentanil
Hemodynamics
Hypotension, Controlled
Pacu
Desflurane
Double-Blind Method
Piperidines
Paranasal Sinuses
medicine
Humans
Prospective Studies
Dexmedetomidine
biology
business.industry
General Medicine
Analgesics, Non-Narcotic
Middle Aged
biology.organism_classification
Surgery
Analgesics, Opioid
Treatment Outcome
Otorhinolaryngology
Anesthesia
Anesthesia Recovery Period
Female
medicine.symptom
Propofol
business
medicine.drug
Subjects
Details
- ISSN :
- 1943572X and 00034894
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- Annals of Otology, Rhinology & Laryngology
- Accession number :
- edsair.doi.dedup.....d364e2b80fbce69b9757aa34f682cf83
- Full Text :
- https://doi.org/10.1177/000348941312200702