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High serum levels of silica nanoparticles in systemic sclerosis patients with occupational exposure: Possible pathogenetic role in disease phenotypes
- Publication Year :
- 2018
-
Abstract
- Background: Systemic sclerosis (SSc) is an autoimmune systemic disease characterized by diffuse fibrosis of skin and visceral organs due to different genetic, infectious, and/or environmental/occupational causative factors, including the inhalation of silica dust. Objectives: To investigate serum trace elements including silicon (s-Si) levels in SSc patients living in a restricted geographical area with high density of worksites with silica exposure hazard. Methods: This case-control study included 80 SSc patients (M:F 10:70; aged 58.4 ± 11.9SD years, mean disease duration 10.1 ± 7.8SD) and 50 age-/sex-matched healthy control subjects consecutively investigated at our University-based Rheumatology Unit. Patients and controls were evaluated for environmental/occupational exposure categories (structured questionnaire), morphological characterization of serum micro-/nanoparticles (Environmental Scanning Electron Microscopy and Energy Dispersive X-ray Spectroscopy microanalysis), and quantitative assessment of trace elements (inductively coupled plasma atomic emission spectroscopy). Results: Among various categories, only occupational exposure to silica dust was recorded in a significant proportion of SSc patients compared to controls (55% vs. 11%; p
- Subjects :
- Lung Diseases
Male
0301 basic medicine
Systemic disease
Gastroenterology
Scleroderma
Systemic sclerosi
0302 clinical medicine
Nanoparticle
Risk Factors
Etiopathogenesis
Inhalation
Silica
Middle Aged
Occupational exposure
Silicon Dioxide
Microparticle
Systemic sclerosis
Female
Interstitial lung fibrosi
Adult
medicine.medical_specialty
Interstitial lung fibrosis
Microparticles
Nanoparticles
Aged
Case-Control Studies
Humans
Lung Diseases, Interstitial
Occupational Exposure
Scleroderma, Systemic
Silica nanoparticles
03 medical and health sciences
Rheumatology
Internal medicine
medicine
Etiopathogenesi
030203 arthritis & rheumatology
business.industry
Systemic
High serum
Case-control study
medicine.disease
Anesthesiology and Pain Medicine
030104 developmental biology
Interstitial
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d360d300e2e3f919ab1484fce67838f2