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Antimycobacterial pimarane diterpenes from the Fungus Diaporthe sp
- Source :
- Bioorganic & Medicinal Chemistry Letters. 13:1253-1255
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Two new pimarane diterpenes, diaportheins A (1) and B (2), were isolated from a culture broth of the fungus Diaporthe sp. BCC 6140. Diaporthein B (2) strongly inhibited the growth of Mycobacterium tuberculosis with the MIC value of 3.1 microg/mL, while diaporthein A (1) showed only mild activity (MIC value of 200 microg/mL).
- Subjects :
- Magnetic Resonance Spectroscopy
Cell Survival
medicine.drug_class
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Microbial Sensitivity Tests
Fungus
Pharmacognosy
Antimycobacterial
Biochemistry
Mycobacterium tuberculosis
chemistry.chemical_compound
Ascomycota
Diaporthe
Chlorocebus aethiops
Drug Discovery
medicine
Animals
Antibiotics, Antitubercular
Vero Cells
Molecular Biology
Antibacterial agent
biology
Chemistry
Organic Chemistry
biology.organism_classification
Terpenoid
Molecular Medicine
Diterpenes
Diterpene
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....d35a70522a6ea41bed751711578521be
- Full Text :
- https://doi.org/10.1016/s0960-894x(03)00111-2