Back to Search
Start Over
Characteristics, comorbidities, and correlates of atypical depression:evidence from the UK Biobank Mental Health Survey
- Source :
- Brailean, A, Curtis, J, Davis, K, Dregan, A & Hotopf, M 2019, ' Characteristics, comorbidities, and correlates of atypical depression : evidence from the UK Biobank Mental Health Survey ', Psychological medicine . https://doi.org/10.1017/S0033291719001004
- Publication Year :
- 2019
-
Abstract
- BackgroundDepression is a heterogeneous disorder with multiple aetiological pathways and multiple therapeutic targets. This study aims to determine whether atypical depression (AD) characterized by reversed neurovegetative symptoms is associated with a more pernicious course and a different sociodemographic, lifestyle, and comorbidity profile than nonatypical depression (nonAD).MethodsAmong 157 366 adults who completed the UK Biobank Mental Health Questionnaire (MHQ), N = 37 434 (24%) met the DSM-5 criteria for probable lifetime major depressive disorder (MDD) based on the Composite International Diagnostic Interview Short Form. Participants reporting both hypersomnia and weight gain were classified as AD cases (N = 2305), and the others as nonAD cases (N = 35 129). Logistic regression analyses were conducted to examine differences between AD and nonAD in depression features, sociodemographic and lifestyle factors, lifetime adversities, psychiatric and physical comorbidities.ResultsPersons with AD experienced an earlier age of depression onset, longer, more severe and recurrent episodes, and higher help-seeking rates than nonAD persons. AD was associated with female gender, unhealthy behaviours (smoking, social isolation, low physical activity), more lifetime deprivation and adversity, higher rates of comorbid psychiatric disorders, obesity, cardiovascular disease (CVD), and metabolic syndrome. Sensitivity analyses comparing AD persons with those having typical neurovegetative symptoms (hyposomnia and weight loss) revealed similar results.ConclusionsThese findings highlight the clinical and public health significance of AD as a chronic form of depression, associated with high comorbidity and lifetime adversity. Our findings have implications for predicting depression course and comorbidities, guiding research on aetiological mechanisms, planning service use and informing therapeutic approaches.
- Subjects :
- Male
medicine.medical_specialty
obesity
socioeconomic disadvantage
Bipolar Disorder
depression course
Comorbidity
Disease
unhealthy lifestyle
metabolic syndrome
03 medical and health sciences
0302 clinical medicine
cardiovascular disease
psychiatric comorbidities
Surveys and Questionnaires
Prevalence
medicine
Humans
Age of Onset
Social isolation
Psychiatry
Atypical depression
atypical depression
Applied Psychology
Depression (differential diagnoses)
Aged
Metabolic Syndrome
Psychiatric Status Rating Scales
Depressive Disorder, Major
business.industry
Public health
Middle Aged
medicine.disease
Anxiety Disorders
Health Surveys
Mental health
United Kingdom
030227 psychiatry
Psychiatry and Mental health
Major depressive disorder
Female
medicine.symptom
business
Adverse life events
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Database :
- OpenAIRE
- Journal :
- Brailean, A, Curtis, J, Davis, K, Dregan, A & Hotopf, M 2019, ' Characteristics, comorbidities, and correlates of atypical depression : evidence from the UK Biobank Mental Health Survey ', Psychological medicine . https://doi.org/10.1017/S0033291719001004
- Accession number :
- edsair.doi.dedup.....d35a506f93aec7d1b3c7272733b8704c