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The mannan-binding lectin pathway of complement activation: biology and disease association
- Source :
- Aarhus University, Petersen, S V, Thiel, S & Jensenius, J C 2001, ' The mannan-binding lectin pathway of complement activation: biology and disease association. ', Molecular Immunology, vol. 38, no. 2-3, pp. 133-49 ., Petersen, S V, Thiel, S & Jensenius, J C 2001, ' The mannan-binding lectin pathway of complement activation: biology and disease association ', Molecular Immunology, vol. 38, pp. 133-149 .
- Publication Year :
- 2001
-
Abstract
- Mannan-binding lectin (MBL) is a plasma protein found in association with several serine proteases (MASPs) forming the MBL complex. MBL recognises carbohydrate structures arranged in a particular geometry, such as those found on the surface of micro-organisms. When bound to e.g. bacteria the MBL complex will initiate the activation of the complement cascade. Mounting evidence supports the importance of the MBL pathway of complement activation in innate immunity. In this review, we focus on the structure and function of the proteins within the MBL pathway and address the properties of the pathway as an initiator of the host response against potential pathogenic micro-organisms. Udgivelsesdato: 2001-Aug
- Subjects :
- Immunology
Molecular Sequence Data
chemical and pharmacologic phenomena
Biology
Communicable Diseases
Autoimmune Diseases
Mannans
Classical complement pathway
Lectins
medicine
Amino Acid Sequence
Molecular Biology
Complement Activation
Mannan-binding lectin
Complement component 2
Blood Proteins
bacterial infections and mycoses
MBL deficiency
medicine.disease
Collectins
Immunity, Innate
Complement system
Immunity, Natural
Biochemistry
Lectin pathway
Alternative complement pathway
Complement membrane attack complex
Carrier Proteins
Subjects
Details
- ISSN :
- 01615890
- Volume :
- 38
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Molecular immunology
- Accession number :
- edsair.doi.dedup.....d352bdd60b3b4b22e4df358dc6cab28d