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Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2
- Source :
- Stem Cell Reports
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- SARS-CoV-2 infection is associated with lower blood oxygen levels, even in patients without hypoxia requiring hospitalization. This discordance illustrates the need for a more unifying explanation as to whether SARS-CoV-2 directly or indirectly affects erythropoiesis. Here, we show significantly enriched CD71+ erythroid precursors/progenitors in the blood circulation of COVID-19 patients. We found that these cells have distinctive immunosuppressive properties. In agreement, we observed a strong negative correlation between the frequency of these cells with T and B cell proportions in COVID-19 patients. The expansion of these CD71+ erythroid precursors/progenitors was negatively correlated with the hemoglobin levels. A subpopulation of abundant erythroid cells, CD45+ CD71+ cells, co-express ACE2, TMPRSS2, CD147, and CD26, and these can be infected with SARS-CoV-2. In turn, pre-treatment of erythroid cells with dexamethasone significantly diminished ACE2/TMPRSS2 expression and subsequently reduced their infectivity with SARS-CoV-2. This provides a novel insight into the impact of SARS-CoV-2 on erythropoiesis and hypoxia seen in COVID-19 patients.<br />In this article Elahi and colleagues show that COVID-19 infection is associated with significant expansion of erythroid precursors/progenitors in the blood of patients. These cells suppress patients' immune response against SARS-CoV-2 infection. Also, they express ACE2 and TMPRSS2 and get infected with SARS-CoV-2. In turn, pre-treatment with dexamethasone significantly diminishes ACE2/TMPRSS2 expression and subsequently reduces their infectivity with SARS-CoV-2.
- Subjects :
- Male
0301 basic medicine
T-Lymphocytes
Adaptive Immunity
Biochemistry
Hemoglobins
Mice
0302 clinical medicine
Erythropoiesis
skin and connective tissue diseases
Aged, 80 and over
Erythroid Precursor Cells
Infectivity
B-Lymphocytes
Mice, Inbred BALB C
0303 health sciences
Erythroid precursors/progenitors
Serine Endopeptidases
Middle Aged
Acquired immune system
3. Good health
Cell biology
RBCs
medicine.anatomical_structure
030220 oncology & carcinogenesis
CD71+ erythroid cells
Female
Angiotensin-Converting Enzyme 2
medicine.symptom
medicine.drug
Adult
Adolescent
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
dexamethasone
Transferrin receptor
Biology
TMPRSS2
Article
Young Adult
03 medical and health sciences
Genetics
medicine
Animals
Humans
Lymphocyte Count
Progenitor cell
Dexamethasone
B cell
Aged
030304 developmental biology
SARS-CoV-2
fungi
COVID-19
Cell Biology
Hypoxia (medical)
Oxygen
030104 developmental biology
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 22136711
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Stem Cell Reports
- Accession number :
- edsair.doi.dedup.....d34c8f049eadbb85600593c53aea182f