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A controlled study to investigate anti-diarrhoeal effect of the stem-bark fractions of Terminalia avicennioides in laboratory animal models
- Source :
- International Journal of Veterinary Science and Medicine, Vol 5, Iss 1, Pp 14-22 (2017)
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Due to the shortcomings associated with modern synthetic antidiarrhoeal drugs, it is important to find newer, safer and cheaper antidiarrhoeal agents from natural sources. The study was conducted to evaluate the anti-diarrhoeal activity of the fractions of the stem-bark of Terminalia avicennioides in laboratory animal models. The effect of different concentrations (1.0 × 10−3, 2.0 × 10−3, 4.0 × 10−3 and 8.0 × 10−3 mg/mL) of the aqueous methanol (AMF), ethyl acetate (EAF) and hexane (HXF) fractions of T. avicennioides were tested against spontaneous and acetylcholine-induced contractions of rabbit jejunum as well as on histamine-induced contraction of guinea pig ileum. Similarly, the effects of the AMF on gastro-intestinal transit time, castor oil-induced diarrhoea and castor oil-induced enteropooling were evaluated. The AMF, EAF and HXF at concentrations of 1.0 × 10−3, 2.0 × 10−3, 4.0 × 10−3 and 8.0 × 10−3 mg/mL attenuated the contractile effects of both the spontaneous and acetylcholine-induced contractions of rabbit jejunum and that of histamine-induced contraction of guinea pig ileum in a concentration-dependent manner. The AMF at doses of 200, 300 and 500 mg/kg produced significant (p
- Subjects :
- 0301 basic medicine
Veterinary medicine
medicine.drug_class
Ethyl acetate
Rabbit
Gastro-intestinal transit time
Jejunum
Guinea pig
03 medical and health sciences
chemistry.chemical_compound
Antidiarrhoeal
medicine
Anti-diarrhoeal
Terminalia avicennioides
Castor oil
Stem bark
lcsh:Veterinary medicine
General Veterinary
Traditional medicine
biology
Chemistry
Laboratory Animal Models
biology.organism_classification
030104 developmental biology
medicine.anatomical_structure
lcsh:SF600-1100
medicine.drug
Subjects
Details
- ISSN :
- 23144599
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- International Journal of Veterinary Science and Medicine
- Accession number :
- edsair.doi.dedup.....d345d9df0bdcadb28343f66a2b5fc1ee