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Decreased frequency, but normal functional integrity of mesenchymal stromal cells derived from untreated and Imatinib-treated chronic myeloid leukemia patients
- Source :
- Leukemia Research. 38:594-600
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- In vitro, Imatinib inhibits the proliferation and stimulates the osteogenic and adipogenic differentiation of mesenchymal stromal cells (MSC). However, it is unknown whether Imatinib affects the biology of MSC in vivo. We asked whether MSC from long-term Imatinib-treated CML patients were affected by the in vivo treatment. MSC from untreated and Imatinib-treated patients displayed normal functional properties (i.e. proliferation, immunophenotype, differentiation and hematopoietic supportive capacity) - but a decreased frequency. In vitro, Imatinib lost its effect when discontinued; which suggest that it has a reversible effect on MSC. Therefore it might lose its effect on MSC after discontinuation in vivo.
- Subjects :
- Cancer Research
medicine.medical_specialty
Fusion Proteins, bcr-abl
Antineoplastic Agents
Piperazines
Immunophenotyping
In vivo
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
hemic and lymphatic diseases
Internal medicine
Humans
Medicine
neoplasms
business.industry
Mesenchymal stem cell
Myeloid leukemia
Cell Differentiation
Mesenchymal Stem Cells
Imatinib
Hematology
In vitro
Haematopoiesis
Phenotype
Pyrimidines
Endocrinology
Oncology
Adipogenesis
Benzamides
Imatinib Mesylate
Cancer research
business
medicine.drug
Subjects
Details
- ISSN :
- 01452126
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Leukemia Research
- Accession number :
- edsair.doi.dedup.....d332ac3910c791466a3b152aaf8355f3