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Conservation of Intronic Sequences in Vertebrate Mitochondrial Solute Carrier Genes (Zebrafish, Chicken, Mouse and Human)
- Source :
- Non-Coding RNA, Vol 5, Iss 1, p 4 (2019), Non-Coding RNA, Volume 5, Issue 1
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- The conservation of intronic sequences was studied in the mitochondrial solute carrier (SLC25A*) genes of Zebrafish, Chicken, Mouse and Human. These genes are homologous and the coding sequences have been well conserved throughout Vertebrates, but the corresponding intronic sequences have been extensively re-edited. However, significant segments of Zebrafish introns are conserved in Chicken, Mouse and Human in carriers SLC25A3, SLC25A21, SLC25A25, SLC25A26, and SLC25A36<br />Chicken intron segments are conserved in Mouse or Human in three additional carriers, namely SLC25A12, SLC25A13, and SLC25A29. Thus, a quota of the intronic sequences of Euteleostomi has been transferred (through Sarcopterygii) to Birds and (through Sarcopterygii and ancestral Mammals) to Mouse and Human. The degree of conservation of Euteleostomi-derived sequences is low and quite similar in Chicken, Mouse and Human (0.23&ndash<br />0.27%). The overall degree of conservation of Sarcopterygii-derived sequences in Mammals is higher, and it is significantly higher in Human than in Mouse (4.4% and 3.2%, respectively). Some of the conserved intronic sequences of SLC25A3, SLC25A21, SLC25A25, and SLC25A29 are exonized in some transcript variants of Zebrafish, Chicken, Mouse, and Human and, with minor nucleotide changes, in other Birds or Mammals.
- Subjects :
- 0301 basic medicine
Sarcopterygii
animal structures
lcsh:QH426-470
introns
chicken
SLC25A3
Biochemistry
Article
03 medical and health sciences
0302 clinical medicine
biology.animal
Genetics
Homologous chromosome
human
Molecular Biology
Gene
Zebrafish
mouse
biology
Intron
Vertebrate
zebrafish
biology.organism_classification
Solute carrier family
lcsh:Genetics
030104 developmental biology
embryonic structures
biology.protein
030217 neurology & neurosurgery
mitochondrial carriers
Subjects
Details
- ISSN :
- 2311553X
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Non-Coding RNA
- Accession number :
- edsair.doi.dedup.....d31bb9c29ae9fe5840a7100b911250cb