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Analysis of drug prescription in chronic haemodialysis patients
- Source :
- Nephrology Dialysis Transplantation. 17:1819-1824
- Publication Year :
- 2002
- Publisher :
- Oxford University Press (OUP), 2002.
-
Abstract
- Background. Information concerning medication use in Asian haemodialysis patients is sparse. We surveyed prescribed medications and examined the relation between the number of medications and mortality and clinical characteristics in chronic haemodialysis patients, in Okinawa, Japan. Methods. We conducted a cross-sectional multicentre survey in August 1999 and patients were observed during 13 months of follow up. Results. The clinical demographics of 850 chronic haemodialysis patients in seven dialysis units were obtained. Compared with the mean number of medications prescribed in ambulatory patients treated in general practice reported from Ministry of Health and Welfare of Japan (2.7 (n=20716)), the mean number medications in haemodialysis patients was larger (7.2 (n = 850)). The three most prescribed drug types in haemodialysis patients were those related to calcium and phosphate metabolism (88%), antihypertensive agents (71%), and erythropoietin (60%). Among the 850 patients, 38 died during the 13-month follow-up period. The number of medications was positively associated with mortality after adjusting for age, sex, and other clinical factors: the hazard ratio was 1.14 (95% confidence interval 1.03-1.26, P=0.007). A multiple linear regression analysis using the number of medications as a dependent factor and sex and other clinical characteristics as independent factors revealed that male sex (P=0.04), diabetes mellitus (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Cross-sectional study
medicine.medical_treatment
Drug Prescriptions
Diabetes Complications
Pharmacotherapy
Internal medicine
Diabetes mellitus
medicine
Humans
Sex Distribution
Medical prescription
Intensive care medicine
Aged
Transplantation
business.industry
Hazard ratio
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Confidence interval
Cross-Sectional Studies
Nephrology
Ambulatory
Kidney Failure, Chronic
Drug Therapy, Combination
Female
Hemodialysis
business
Subjects
Details
- ISSN :
- 14602385
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....d3185c08929c365c111e2248c174efe2