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Chronic Venous Insufficiency as a Predisposing Factor for Basal Cell Carcinoma on Legs
- Source :
- Annals of vascular surgery. 68
- Publication Year :
- 2020
-
Abstract
- Background The main risk factor associated with basal cell carcinomas (BCCs) is believed to be exposure to ultraviolet radiation (UVR). In the case of lower limb BCC, the frequency is higher in women, possibly because of greater exposure of the leg to UVR. Chronic venous insufficiency (CVI), also more common in women, may have some association with leg BCCs. Methods We retrospectively evaluated the histopathological features of leg BCCs removed between 1993 and 2017 in a tertiary referral center. The patients’ clinical data were obtained from medical records, considering, in particular, CVI. Results We selected 149 patients with leg BCCs, predominately occurring in elderly Caucasian women. Of those, 71 had a clinical diagnosis of CVI in whom the clinical tumor size and frequency of recurrences were significantly higher than patients without CVI. There was an association between clinical diagnosis of CVI and histological findings of (1) follicular induction in epidermis and (2) distal sweat duct hyperplasia. Conclusions CVI, besides the already known UVR exposure, is probably associated with leg BCCs and may determine a worse BCC course.
- Subjects :
- Adult
medicine.medical_specialty
Skin Neoplasms
Time Factors
Chronic venous insufficiency
Sweat duct
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Sex Factors
Risk Factors
Follicular phase
medicine
Humans
Basal cell carcinoma
Risk factor
Aged
Retrospective Studies
Aged, 80 and over
Leg
integumentary system
Tumor size
business.industry
Medical record
General Medicine
Hyperplasia
Middle Aged
medicine.disease
Dermatology
Tumor Burden
Treatment Outcome
Venous Insufficiency
Carcinoma, Basal Cell
Chronic Disease
Surgery
Neoplasm Recurrence, Local
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 16155947
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Annals of vascular surgery
- Accession number :
- edsair.doi.dedup.....d3100917c5c0a5fde06fc3e616dec4c8