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Comparison of the Modulatory Effect on Intestinal Microbiota between Raw and Bran-Fried Atractylodis Rhizoma in the Rat Model of Spleen-Deficiency Syndrome
- Source :
- International Journal of Environmental Research and Public Health, Vol 16, Iss 17, p 3183 (2019), International Journal of Environmental Research and Public Health, Volume 16, Issue 17
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Atractylodis Rhizoma (AR), a kind of well-known traditional Chinese medicine (TCM), has a long history of being used to treat spleen-deficiency syndrome (SDS). Stir frying with bran is a common method of processing AR, as recorded in the Chinese Pharmacopoeia, and is thought to enhance the therapeutic effect in TCM. Our previous studies have confirmed that bran-fried AR is superior to raw AR in terms of the improvement of gastrointestinal tract function. However, the biological mechanism of action is not yet clear. Here, we report the difference between raw and bran-fried AR in terms of the modulatory effect of intestinal microbiota. We found that the composition of intestinal microbiota of SDS rats changed significantly compared with healthy rats and tended to recover to normal levels after treatment with raw and bran-fried AR. Nine bacteria closely related to SDS were identified at the genus level. Among them, the modulatory effect between the raw and bran-fried AR was different. The improved modulation on Bacteroides, Escherichia-Shigella, Phascolarctobacterium, Incertae-Sedis (Defluviitaleaceae Family) and Incertae-Sedis (Erysipelotrichaceae Family) could be the mechanism by which bran-fried AR enhanced the therapeutic effect. Correlation analysis revealed that the modulation on intestinal microbiota was closely related to the secretion and expression of cytokines and gastrointestinal hormones. These findings can help us to understand the role and significance of bran-fried AR against SDS.
- Subjects :
- Dietary Fiber
Male
intestinal microbiota
Health, Toxicology and Mutagenesis
Atractylodis Rhizoma
mechanism
lcsh:Medicine
Spleen
Traditional Chinese medicine
Pharmacology
Article
Rats, Sprague-Dawley
Feces
03 medical and health sciences
0302 clinical medicine
16S rDNA
medicine
Animals
Medicine, Chinese Traditional
bran-fried
spleen-deficiency syndrome
Splenic Diseases
030304 developmental biology
0303 health sciences
Gastrointestinal tract
Bacteria
biology
Bran
lcsh:R
digestive, oral, and skin physiology
Therapeutic effect
Public Health, Environmental and Occupational Health
food and beverages
Atractylodes
biology.organism_classification
Gastrointestinal Microbiome
Rats
Disease Models, Animal
medicine.anatomical_structure
Mechanism of action
030220 oncology & carcinogenesis
medicine.symptom
Bacteroides
Rhizome
Hormone
Subjects
Details
- ISSN :
- 16604601
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....d30cb4c65f7503dda540e227ff212316