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T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells
- Source :
- Immunity. 48:327-338.e5
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Summary Immunosurveillance of secondary lymphoid organs (SLO) is performed by central memory T cells that recirculate through blood. Resident memory T (Trm) cells remain parked in nonlymphoid tissues and often stably express CD69. We recently identified Trm cells within SLO, but the origin and phenotype of these cells remains unclear. Using parabiosis of "dirty" mice, we found that CD69 expression is insufficient to infer stable residence of SLO Trm cells. Restimulation of nonlymphoid memory CD8 + T cells within the skin or mucosa resulted in a substantial increase in bona fide Trm cells specifically within draining lymph nodes. SLO Trm cells derived from emigrants from nonlymphoid tissues and shared some transcriptional and phenotypic signatures associated with nonlymphoid Trm cells. These data indicate that nonlymphoid cells can give rise to SLO Trm cells and suggest vaccination strategies by which memory CD8 + T cell immunosurveillance can be regionalized to specific lymph nodes.
- Subjects :
- Antigens, Differentiation, T-Lymphocyte
0301 basic medicine
genetic structures
Parabiosis
Immunology
chemical and pharmacologic phenomena
CD8-Positive T-Lymphocytes
Lymphocytic Choriomeningitis
Biology
Article
Secondary lymphoid organs
Mice
03 medical and health sciences
0302 clinical medicine
Antigens, CD
medicine
Animals
Immunology and Allergy
Lectins, C-Type
Lymph node
integumentary system
CD69
hemic and immune systems
Phenotype
Cell biology
Mice, Inbred C57BL
Immunosurveillance
030104 developmental biology
Infectious Diseases
medicine.anatomical_structure
Female
Lymph Nodes
Lymph
Immunologic Memory
CD8
030215 immunology
Subjects
Details
- ISSN :
- 10747613
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....d30c5f95671d2fafd1f63c7da708e519