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Anemia in patients with Wegeners granulomatosis
- Source :
- Europe PubMed Central
- Publication Year :
- 2007
- Publisher :
- Dustri-Verlgag Dr. Karl Feistle, 2007.
-
Abstract
- Aims: Anemia is commonly observed among patients with chronic kidney disease (CKD). No such information is available for patients with a history of systemic vasculitis. Methods: We examined the prevalence of anemia, the response to therapy with erythropoiesis-stimulating agents (ESA), and the association of anemia with the kidney function in clinically stable patients with Wegener's granulomatosis in a retrospective, single-center study. Results: The mean hemoglobin concentration of 36 patients (mean age: 58 years; 15 female, 21 male; mean duration of disease: 4.6 years) was 13.0 ±2.1 g/dl, and the mean estimated glomerular filtration rate (eGFR) was 41 ± 21 ml/min/1.73 m 2 . 14 of 36 patients (38.8%) presented with anemia (hemoglobin conccntration < 12 g/dl in women, < 13 g/dl in men, or ESA therapy). In patients with a CKD Stage 3 or 4, anemia was present about twice as much as compared to the Third National Health and Nutrition Examination Survey (NHANES III) population. The hemoglobin concentration, however, was not associated with a change of kidney function (p = 0.1578). Conclusions: We found a higher prevalence of anemia in patients with Wegener's granulomatosis, as compared to the NHANES III population. The hemoglobin concentrations showed no association with changes of kidney function.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Darbepoetin alfa
Anemia
Population
Renal function
Severity of Illness Index
Gastroenterology
Hemoglobins
hemic and lymphatic diseases
Internal medicine
Outpatients
Prevalence
Humans
Medicine
education
Erythropoietin
Retrospective Studies
education.field_of_study
business.industry
Granulomatosis with Polyangiitis
General Medicine
Middle Aged
Prognosis
medicine.disease
Recombinant Proteins
Surgery
Creatinine
Hematinics
Kidney Failure, Chronic
Drug Therapy, Combination
Female
Hemoglobin
business
Glomerular Filtration Rate
Systemic vasculitis
medicine.drug
Kidney disease
Subjects
Details
- ISSN :
- 03010430
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Clinical Nephrology
- Accession number :
- edsair.doi.dedup.....d3013d2fc6028f0f0819710e0b5a71c7