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Translational perspective on epigenetics in cardiovascular disease
- Publication Year :
- 2017
- Publisher :
- Elsevier, 2017.
-
Abstract
- A plethora of environmental and behavioral factors interact, resulting in changes in gene expression and providing a basis for the development and progression of cardiovascular diseases. Heterogeneity in gene expression responses among cells and individuals involves epigenetic mechanisms. Advancing technology allowing genome-scale interrogation of epigenetic marks provides a rapidly expanding view of the complexity and diversity of the epigenome. In this review, the authors discuss the expanding landscape of epigenetic modifications and highlight their importance for future understanding of disease. The epigenome provides a mechanistic link between environmental exposures and gene expression profiles ultimately leading to disease. The authors discuss the current evidence for transgenerational epigenetic inheritance and summarize the data linking epigenetics to cardiovascular disease. Furthermore, the potential targets provided by the epigenome for the development of future diagnostics, preventive strategies, and therapy for cardiovascular disease are reviewed. Finally, the authors provide some suggestions for future directions. (C) 2017 by the American College of Cardiology Foundation.
- Subjects :
- 0301 basic medicine
Epigenomics
Cardiac & Cardiovascular Systems
HISTONE DEACETYLASE
INTRAUTERINE ENVIRONMENT
Disease
BLOOD-LIPIDS
Epigenesis, Genetic
Translational Research, Biomedical
CARDIOMYOCYTE HYPERTROPHY
HDAC
Medicine
CARDIAC-HYPERTROPHY
DNA METHYLATION
Translational Medical Research
1102 Cardiorespiratory Medicine and Haematology
Genetics
LONG NONCODING RNA
Cardiovascular Diseases
Cardiac hypertrophy
DNA methylation
HEART-FAILURE
SELECTIVE HDAC INHIBITORS
Cardiology and Cardiovascular Medicine
Life Sciences & Biomedicine
INHIBITION
Computational biology
Article
1117 Public Health and Health Services
03 medical and health sciences
Transgenerational epigenetics
histones
Humans
Epigenetics
CPT1A LOCUS
EWAS
EPIGENOME-WIDE ASSOCIATION
Science & Technology
Data linking
business.industry
Perspective (graphical)
Epigenome
HUMAN HEART
BODY-MASS INDEX
030104 developmental biology
Cardiovascular System & Hematology
HAT
Cardiovascular System & Cardiology
RNA
methylation
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d2fb23c40bcdaa5c72beef554f5f09d8