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‘Cancer associated fibroblasts’ – more than meets the eye
- Source :
- Trends in Molecular Medicine. 19:447-453
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Cancer associated fibroblasts (CAFs) are a subpopulation of cells that reside within the tumor microenvironment and promotes the transformation process by encouraging tumor growth, angiogenesis, inflammation, and metastasis. CAF-specific proteins serve as both prognostic markers and targets for anticancer drugs. With the growing interest in CAFs, several controversial issues have been raised, including the genomic landscape of these cells, the identity of specific markers, and their cell of origin. Here, we tackle these debated issues and put forward a new definition for 'CAF' as a cell 'state' rather than a cell type. We hope this conceptualization can resolve the ongoing discrepancies revolving around CAF research and aid in designing better anti-cancer treatment strategies.
- Subjects :
- Cell type
Tumor microenvironment
Angiogenesis
Cell of origin
Cell
Fibroblasts
Biology
medicine.disease
Metastasis
medicine.anatomical_structure
Neoplasms
Immunology
Biomarkers, Tumor
Tumor Microenvironment
Cancer research
medicine
Animals
Humans
Molecular Medicine
Cancer-Associated Fibroblasts
Stromal Cells
Stem cell
Molecular Biology
Subjects
Details
- ISSN :
- 14714914
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Trends in Molecular Medicine
- Accession number :
- edsair.doi.dedup.....d2f4328443d0cf1b03f41c741778d39f