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Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System
- Publication Year :
- 2003
- Publisher :
- Cold Spring Harbor Laboratory Press, 2003.
-
Abstract
- We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.
- Subjects :
- Nervous system
Guanine
Transcription, Genetic
Molecular Sequence Data
Receptors, Cell Surface
Biology
Nervous System
Transcriptome
Cytosine
Mice
Settore BIO/13 - Biologia Applicata
Transcription (biology)
Chloride Channels
GTP-Binding Proteins
Databases, Genetic
Genetics
medicine
Gene family
Coding region
Animals
Humans
Genomic library
Nervous System Physiological Phenomena
Letters
Amino Acid Sequence
Peptide sequence
Gene
Genetics (clinical)
Phylogeny
Gene Library
Brain Chemistry
Neurons
Adenine
Neuropeptides
Neurodegenerative Diseases
medicine.anatomical_structure
Genes
Calcium
Calcium Channels
Trinucleotide Repeat Expansion
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d2ebbc46f623e2e1a87f5c795a2ffdd5