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Analysis of the Mouse Transcriptome for Genes Involved in the Function of the Nervous System

Authors :
Gustincich, S.
Batalov, S.
Beisel, K. W.
Bono, H.
Carninci, P.
Fletcher, C. F.
Grimmond, S.
Hirokawa, N.
Jarvis, E. D.
Jegla, T.
Kawasawa, Y.
Lemieux, J.
Miki, H.
Raviola, E.
Teasdale, R. D.
Tominaga, N.
Yagi, K.
Zimmer, A.
Arakawa, T.
Waki, K.
Kawai, J.
Hayashizaki, Y.
Okazaki, Y.
Publication Year :
2003
Publisher :
Cold Spring Harbor Laboratory Press, 2003.

Abstract

We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function.We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins.We also identified previously unknown candidates for secreted neuroactive molecules.The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....d2ebbc46f623e2e1a87f5c795a2ffdd5