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Efficacy of photodynamic therapy combined with minocycline for treatment of moderate to severe facial acne vulgaris and influence on quality of life
- Source :
- Medicine
- Publication Year :
- 2017
- Publisher :
- Wolters Kluwer Health, 2017.
-
Abstract
- Background: Acne vulgaris is a prevalent skin disorder impairing both physical and psychosocial health. This study was designed to investigate the effectiveness of photodynamic therapy (PDT) combined with minocycline in moderate to severe facial acne and influence on quality of life (QOL). Methods: Ninety-five patients with moderate to severe facial acne (Investigator Global Assessment [IGA] score 3–4) were randomly treated with PDT and minocycline (n = 48) or minocycline alone (n = 47). All patients took minocycline hydrochloride 100 mg/d for 4 weeks, whereas patients in the minocycline plus PDT group also received 4 times PDT treatment 1 week apart. IGA score, lesion counts, Dermatology Life Quality Index (DLQI), and safety evaluation were performed before treatment and at 2, 4, 6, and 8 weeks after enrolment. Results: There were no statistically significant differences in characteristics between 2 treatment groups at baseline. Minocycline plus PDT treatment led to a greater mean percentage reduction from baseline in lesion counts versus minocycline alone at 8 weeks for both inflammatory (−74.4% vs −53.3%; P
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Photodynamic therapy
Minocycline
Severity of Illness Index
law.invention
030207 dermatology & venereal diseases
03 medical and health sciences
Young Adult
0302 clinical medicine
Quality of life
Randomized controlled trial
law
Severity of illness
Acne Vulgaris
Medicine
Combined Modality Therapy
Humans
Prospective Studies
Acne
Chi-Square Distribution
business.industry
General Medicine
Clinical Trial/Experimental Study
medicine.disease
Dermatology
Treatment Outcome
photodynamic therapy
quality of life
Photochemotherapy
030220 oncology & carcinogenesis
Female
business
Psychosocial
Facial Dermatoses
medicine.drug
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 96
- Issue :
- 51
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....d2e5e6e91b93d38062e57e3eabad421f