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Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis: trivariate twin modelling and implications for genetic design
- Source :
- Hines, L A, Morley, K I, Rijsdijk, F, Strang, J, Agrawal, A, Nelson, E C, Statham, D, Martin, N G & Lynskey, M T 2018, ' Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis : trivariate twin modelling and implications for genetic design ', Psychological Medicine, vol. 48, no. 16, pp. 2786-2793 . https://doi.org/10.1017/S0033291718000478, Hines, L A, Morley, K I, Rijsdijk, F V, Strang, J, Agrawal, A, Nelson, E C, Statham, D, Martin, N G & Lynskey, M T 2018, ' Overlap of heritable influences between cannabis use disorder, frequency of use and opportunity to use cannabis : trivariate twin modelling and implications for genetic design ', Psychological Medicine, vol. 48, no. 16, pp. 2786-2793 . https://doi.org/10.1017/S0033291718000478
- Publication Year :
- 2018
- Publisher :
- Cambridge University Press (CUP), 2018.
-
Abstract
- BackgroundThe genetic component of Cannabis Use Disorder may overlap with influences acting more generally on early stages of cannabis use. This paper aims to determine the extent to which genetic influences on the development of cannabis abuse/dependence are correlated with those acting on the opportunity to use cannabis and frequency of use.MethodsA cross-sectional study of 3303 Australian twins, measuring age of onset of cannabis use opportunity, lifetime frequency of cannabis use, and lifetime DSM-IV cannabis abuse/dependence. A trivariate Cholesky decomposition estimated additive genetic (A), shared environment (C) and unique environment (E) contributions to the opportunity to use cannabis, the frequency of cannabis use, cannabis abuse/dependence, and the extent of overlap between genetic and environmental factors associated with each phenotype.ResultsVariance components estimates were A = 0.64 [95% confidence interval (CI) 0.58–0.70] and E = 0.36 (95% CI 0.29–0.42) for age of opportunity to use cannabis, A = 0.74 (95% CI 0.66–0.80) and E = 0.26 (95% CI 0.20–0.34) for cannabis use frequency, and A = 0.78 (95% CI 0.65–0.88) and E = 0.22 (95% CI 0.12–0.35) for cannabis abuse/dependence. Opportunity shares 45% of genetic influences with the frequency of use, and only 17% of additive genetic influences are unique to abuse/dependence from those acting on opportunity and frequency.ConclusionsThere are significant genetic contributions to lifetime cannabis abuse/dependence, but a large proportion of this overlaps with influences acting on opportunity and frequency of use. Individuals without drug use opportunity are uninformative, and studies of drug use disorders must incorporate individual exposure to accurately identify aetiology.
- Subjects :
- Adult
Male
Drug
Marijuana Abuse
media_common.quotation_subject
Frequency of use
03 medical and health sciences
0302 clinical medicine
Journal Article
medicine
Humans
Genetic Predisposition to Disease
Registries
030212 general & internal medicine
Applied Psychology
Behavioural genetics
media_common
Cannabis use disorder
biology
business.industry
Addiction
Australia
biology.organism_classification
medicine.disease
Confidence interval
Psychiatry and Mental health
Cross-Sectional Studies
Female
Marijuana Use
Cannabis
Age of onset
business
030217 neurology & neurosurgery
Demography
Subjects
Details
- ISSN :
- 14698978 and 00332917
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Psychological Medicine
- Accession number :
- edsair.doi.dedup.....d2e467ca01b30c8ccea655f97d3ab4a9