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Metastasis-associated fibroblasts: an emerging target for metastatic cancer
- Source :
- Biomarker Research, Biomarker Research, Vol 9, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
-
Abstract
- Metastasis suggests a poor prognosis for cancer patients, and treatment strategies for metastatic cancer are still very limited. Numerous studies have shown that cancer-associated fibroblasts (CAFs), a large component of the tumor microenvironment, contribute to tumor metastasis. Stromal fibroblasts at metastatic sites are different from CAFs within primary tumors and can be termed metastasis-associated fibroblasts (MAFs), and they also make great contributions to the establishment of metastatic lesions and the therapeutic resistance of metastatic tumors. MAFs are capable of remodeling the extracellular matrix of metastatic tumors, modulating immune cells in the tumor microenvironment, promoting angiogenesis and enhancing malignant tumor phenotypes. Thus, MAFs can help establish premetastatic niches and mediate resistance to therapeutic strategies, including immunotherapy and antiangiogenic therapy. The results of preclinical studies suggest that targeting MAFs can alleviate the progression of metastatic cancer and mitigate therapeutic resistance, indicating that MAFs are a promising target for metastatic cancer. Here, we comprehensively summarize the existing evidence on MAFs and discuss their origins, generation, functions and related therapeutic strategies in an effort to provide a better understanding of MAFs and offer treatment perspectives for metastatic cancer.
- Subjects :
- 0301 basic medicine
Angiogenesis
medicine.medical_treatment
Clinical Biochemistry
RM1-950
Review
Metastasis-associated fibroblasts
Metastasis
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
Immune system
Medicine
Cancer-associated fibroblasts
Tumor microenvironment
business.industry
Biochemistry (medical)
Cancer
Immunotherapy
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Cancer treatment
Cancer research
Molecular Medicine
Cancer-Associated Fibroblasts
Therapeutics. Pharmacology
business
Metastatic cancer
Subjects
Details
- ISSN :
- 20507771
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Biomarker research
- Accession number :
- edsair.doi.dedup.....d2cbc013b5682bfdc5fe68957d496d5a