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A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation†
- Source :
- Chemical Science
- Publication Year :
- 2021
- Publisher :
- The Royal Society of Chemistry, 2021.
-
Abstract
- β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced palladium catalyst system with the Ruphos ligand allows for selective cycloaminocarbonylations to give diverse fluorinated β-lactams in high yields.<br />β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics.
- Subjects :
- Trifluoromethyl
010405 organic chemistry
Ligand
chemistry.chemical_element
General Chemistry
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Catalysis
chemistry.chemical_compound
Chemistry
chemistry
β lactams
polycyclic compounds
Palladium catalyst
Carbonylation
Palladium
Subjects
Details
- Language :
- English
- ISSN :
- 20416539 and 20416520
- Volume :
- 12
- Issue :
- 31
- Database :
- OpenAIRE
- Journal :
- Chemical Science
- Accession number :
- edsair.doi.dedup.....d2acbfe68e49726a686540fb7151ec5c