Back to Search Start Over

Complete head cerebral sensitivity mapping for diffuse correlation spectroscopy using subject-specific magnetic resonance imaging models

Authors :
Melissa M. Wu
Katherine Perdue
Suk-Tak Chan
Kimberly A. Stephens
Bin Deng
Maria Angela Franceschini
Stefan A. Carp
Source :
Biomed Opt Express
Publication Year :
2022
Publisher :
Optica Publishing Group, 2022.

Abstract

We characterize cerebral sensitivity across the entire adult human head for diffuse correlation spectroscopy, an optical technique increasingly used for bedside cerebral perfusion monitoring. Sixteen subject-specific magnetic resonance imaging-derived head models were used to identify high sensitivity regions by running Monte Carlo light propagation simulations at over eight hundred uniformly distributed locations on the head. Significant spatial variations in cerebral sensitivity, consistent across subjects, were found. We also identified correlates of such differences suitable for real-time assessment. These variations can be largely attributed to changes in extracerebral thickness and should be taken into account to optimize probe placement in experimental settings.

Details

Language :
English
Database :
OpenAIRE
Journal :
Biomed Opt Express
Accession number :
edsair.doi.dedup.....d292c3e0c271551bff62792582cbac02