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Systemic lupus erythematosus gastrointestinal involvement: a computed tomography-based assessment
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Systemic lupus erythematosus (SLE) gastrointestinal (GI) complication is characterized by multi-segment and multi-compartment involvement. The aim of this study is to develop a computed tomography (CT) image-based system for disease evaluation. SLE patients with GI involvement from two independent cohorts were retrospectively included. Baseline abdominal CT scan with intravenous and oral contrast was obtained from each individual. A CT scoring system incorporating the extent of GI tract involvement and intestinal wall thickness, along with extra-GI compartment involvement, was developed and validated. The outcome measurement was the time to GI functional recovery, defined as the time to tolerable per os (PO) intake ≥50% of ideal calories (PO50). A total of 54 and 37 patients with SLE GI involvement were enrolled in the derivation and validation cohorts, respectively. The CT scores for SLE GI involvement were positively correlated with patients’ time to PO50 (r = 0.57, p 3 incurred a significantly prolonged recovery with a median time to PO50 of 13 days (p
- Subjects :
- Adult
Male
medicine.medical_specialty
Scoring system
Abdominal ct
lcsh:Medicine
Computed tomography
Disease
Gastroenterology
Article
03 medical and health sciences
Systemic lupus erythematosus
0302 clinical medicine
Internal medicine
medicine
Humans
Lupus Erythematosus, Systemic
Derivation
lcsh:Science
030203 arthritis & rheumatology
Multidisciplinary
Lupus erythematosus
medicine.diagnostic_test
business.industry
lcsh:R
medicine.disease
Functional recovery
Gastrointestinal Tract
Treatment Outcome
Female
lcsh:Q
030211 gastroenterology & hepatology
Tomography, X-Ray Computed
business
Complication
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....d28371324cc5b8ec963860f8a7a3b9e1