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Glutamatergic systems and memory mechanisms underlying opioid addiction
- Source :
- Heinsbroek, J A, De Vries, T J & Peters, J 2021, ' Glutamatergic systems and memory mechanisms underlying opioid addiction ', Cold Spring Harbor perspectives in medicine, vol. 11, no. 3, a039602, pp. 1-31 . https://doi.org/10.1101/cshperspect.a039602, Cold Spring Harb Perspect Med, Cold Spring Harbor perspectives in medicine, 11(3):a039602, 1-31. Cold Spring Harbor Laboratory Press, Heinsbroek, J A, de Vries, T J & Peters, J 2021, ' Glutamatergic systems and memory mechanisms underlying opioid addiction ', Cold Spring Harbor perspectives in medicine, vol. 11, no. 3, a039602, pp. 1-31 . https://doi.org/10.1101/cshperspect.a039602
- Publication Year :
- 2021
-
Abstract
- Glutamate is the main excitatory neurotransmitter in the brain and is of critical importance for the synaptic and circuit mechanisms that underlie opioid addiction. Opioid memories formed over the course of repeated drug use and withdrawal can become powerful stimuli that trigger craving and relapse, and glutamatergic neurotransmission is essential for the formation and maintenance of these memories. In this review, we discuss the mechanisms by which gluta-mate, dopamine, and opioid signaling interact to mediate the primary rewarding effects of opioids, and cover the glutamatergic systems and circuits that mediate the expression, extinc-tion, and reinstatement of opioid seeking over the course of opioid addiction.
- Subjects :
- 0301 basic medicine
Dopamine
Glutamic Acid
Craving
Neurotransmission
Synaptic Transmission
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Glutamatergic
0302 clinical medicine
Reward
SDG 3 - Good Health and Well-being
Memory
medicine
Animals
Humans
Opioid addiction
Morphine
business.industry
Glutamate receptor
Brain
Extinction (psychology)
Opioid-Related Disorders
030104 developmental biology
Opioid
medicine.symptom
business
Corrigendum
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 21571422
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cold Spring Harbor perspectives in medicine
- Accession number :
- edsair.doi.dedup.....d27ea02f3becb3ebdb68654ca3f9bd0d