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A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease
- Source :
- Chemical Communications. 56:1625-1628
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease.
- Subjects :
- Male
Genetically modified mouse
Mice, Transgenic
Molecular Dynamics Simulation
010402 general chemistry
01 natural sciences
Catalysis
Alzheimer Disease
Limit of Detection
2-Naphthylamine
Nitriles
Materials Chemistry
Animals
Fluorescent Dyes
Amyloid beta-Peptides
010405 organic chemistry
Chemistry
Metals and Alloys
Brain
General Chemistry
Fluorescence
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Mice, Inbred C57BL
Molecular Docking Simulation
Spectrometry, Fluorescence
Ceramics and Composites
Biophysics
Female
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....d2765d6816358c2cdf977f6fd8e45340