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Nicotinamide Nâmethyltransferase in nonmelanoma skin cancers
- Source :
- European Journal of Clinical Investigation. 49
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- BACKGROUND Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) represent the most common forms of nonmelanoma skin cancers (NMSCs). Although successful treatment of these neoplasms is based on surgical excision, an increasing number of BCCs relapses and many SCCs display high rates of recurrence and metastasis. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme, which was found to be upregulated in different solid tumours. However, there are no data regarding enzyme expression in NMSCs. The aim of this study was therefore to evaluate the potential involvement of NNMT in BCCs and SCCs. MATERIALS AND METHODS Immunohistochemical analyses were carried out on 40 BCC cases and 39 SCC cases, to evaluate enzyme expression in tumour and surrounding healthy margins. Moreover, the relationship between NNMT intratumour levels and clinico-pathological parameters were explored. RESULTS Nicotinamide N-methyltransferase was found to be overexpressed in BCCs compared with control tissues, while a significant enzyme downregulation was detected in SCCs with respect to corresponding healthy margins. In addition, NNMT levels were negatively related to aggressiveness of both BCCs (distinguishing between infiltrative and nodular tumours) and SCCs (considering head and neck forms and tumours of the extremities and trunk). CONCLUSIONS These evidences seem to demonstrate that the different NNMT dysregulation detected in BCC and SCC may be the result of important biological traits distinctively characterizing these two forms within NMSCs. In addition, enzyme levels seem to be inversely correlated with tumour aggressiveness, thus suggesting the potential suitability of the enzyme as a prognostic biomarker for both neoplasms.
- Subjects :
- Adult
Male
Skin Neoplasms
Clinical Biochemistry
Down-Regulation
Nicotinamide N-methyltransferase
030204 cardiovascular system & hematology
Biochemistry
Metastasis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
Nicotinamide N-Methyltransferase
medicine
Humans
Neoplasm Invasiveness
Basal cell carcinoma
030212 general & internal medicine
Head and neck
Aged
Retrospective Studies
Aged, 80 and over
chemistry.chemical_classification
Nicotinamide
Squamous Cell Carcinoma of Head and Neck
business.industry
General Medicine
Middle Aged
medicine.disease
Immunohistochemistry
Tumor Burden
stomatognathic diseases
Enzyme
chemistry
Carcinoma, Basal Cell
Head and Neck Neoplasms
Carcinoma, Squamous Cell
Cancer research
Female
business
Subjects
Details
- ISSN :
- 13652362 and 00142972
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....d26c4e73db8415467669428aec3a2c60