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Circulating Aminoterminal Propeptide of Type III Procollagen as a Biomarker of Cardiovascular Events in Patients Undergoing Hemodialysis
- Source :
- Journal of Atherosclerosis and Thrombosis
- Publication Year :
- 2019
- Publisher :
- Japan Atherosclerosis Society, 2019.
-
Abstract
- Aim: Type III collagen abundantly exists in the cardiovascular system, including the aorta and heart. We prospectively investigated whether serum levels of aminoterminal propeptide of type III procollagen (PIIINP), a circulating biomarker of cardiovascular fibrosis, could predict cardiovascular events in patients undergoing hemodialysis. Methods: Serum PIIINP concentrations were measured in 244 patients undergoing maintenance hemodialysis (men, 126; women, 118; mean age, 64 ± 11 years; dialysis duration, 11.5 ± 7.8 years) by immunoradiometric assay in February 2005. The endpoint was cardiovascular events, and the patients were followed up until the endpoint was reached, or until January 31, 2011. Results: During the follow-up for 4.7 ± 1.8 years, cardiovascular events occurred in 78 (30.3%) of 244 patients. Stepwise Cox hazard analysis revealed that cardiovascular events were associated with increased serum PIIINP concentration (1 U/mL; hazard ratio, 1.616; P = 0.0001). The median serum PIIINP concentrations were higher in patients with cardiovascular events than in those without (2.30 ± 0.19 U/mL vs 1.30 ± 0.03 U/mL; P < 0.0001). When the patients were assigned to subgroups based on serum PIIINP cut-off value for cardiovascular events of 1.75 U/mL, defined by receiver operating characteristic analysis, cardiovascular event-free survival rates at 5 years were lower (P = 0.0001) in the subgroup of serum PIIINP ≥ 1.75 U/mL than in that of serum PIIINP < 1.75 U/mL (31.9% vs 88.2%). Conclusions: Serum PIIINP could be a new biomarker for predicting the cardiovascular events in patients undergoing hemodialysis.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
030204 cardiovascular system & hematology
Left ventricular hypertrophy
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Fibrosis
Renal Dialysis
Risk Factors
Internal medicine
Internal Medicine
medicine
Humans
Cardiovascular fibrosis
Dialysis
Aged
Immunoradiometric assay
business.industry
Biochemistry (medical)
Hazard ratio
Aortic stiffness
Middle Aged
medicine.disease
Prognosis
Peptide Fragments
Survival Rate
Procollagen peptidase
ROC Curve
Cardiovascular Diseases
Hemodialysis
Biomarker (medicine)
Kidney Failure, Chronic
Original Article
Female
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Procollagen
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 18803873 and 13403478
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Atherosclerosis and Thrombosis
- Accession number :
- edsair.doi.dedup.....d2697ef132b7356db70f039d320340ad