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A Common Neuronal Response to Alphaherpesvirus Infection
- Source :
- Journal of Neuroimmune Pharmacology. 5:418-427
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Alphaherpesviruses are a subfamily of the Herpesviridae that can invade the nervous system and establish either lytic or latent infections. The establishment of latent infection can occur only in neurons, indicating a unique virus-host interaction in these cells. Here, we compare results from seven microarray studies that focused on the host response of either neural tissue or isolated neurons to alphaherpesvirus infection. These studies utilized either herpes simplex virus type 1 or pseudorabies virus as the infectious agent. From these data, we have found common host responses spanning a variety of infection models in different species, with different herpesvirus strains, and during all phases of infection including lytic, latent, and reactivation. The repeated observation of transcriptional effects on these genes and gene families indicates their likely importance in host defenses or the viral infectious process. We discuss the possible role of these different genes and genes families in alphaherpesvirus infection.
- Subjects :
- Gene Expression Regulation, Viral
Pharmacology
biology
Neuroimmunomodulation
viruses
Immunology
Neuroscience (miscellaneous)
Pseudorabies
Herpesviridae Infections
Alphaherpesvirinae
biology.organism_classification
medicine.disease_cause
Virology
Article
Virus
Herpesviridae
Herpes simplex virus
Lytic cycle
medicine
Humans
Immunology and Allergy
Gene family
Signal Transduction
Subjects
Details
- ISSN :
- 15571904 and 15571890
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmune Pharmacology
- Accession number :
- edsair.doi.dedup.....d266ade7fa7b15c2bc10781b297521c0