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The anticancer activity of an air-stable Pd(<scp>i</scp>)-NHC (NHC = N-heterocyclic carbene) dimer
- Source :
- CHEMICAL COMMUNICATIONS
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.
- Subjects :
- ISOCYANIDES
Cell Survival
Stereochemistry
Dimer
SUPPORTED PRECATALYSTS
BRIDGING ALLYL
Antineoplastic Agents
Drug Screening Assays
Catalysis
Cell Line
Dose-Response Relationship
Structure-Activity Relationship
chemistry.chemical_compound
CYCLOPENTADIENYL
Coordination Complexes
Heterocyclic Compounds
Cell Line, Tumor
Cell Proliferation
Dimerization
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Methane
Molecular Structure
Palladium
Materials Chemistry
Settore CHIM/03 - Chimica Generale e Inorganica
Tumor
Chemistry
Metals and Alloys
Antitumor
General Chemistry
REACTIVITY
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
UNUSUAL COORDINATION BEHAVIOR
DINUCLEAR PALLADIUM(I)
Ceramics and Composites
BINUCLEAR PALLADIUM(I) COMPLEXES
LIGANDS
Drug
BOND
Carbene
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....d23ee0d5d1dfa36f696d52687a730004