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A Tertiary Academic Medical Center Blood Bank's Experience With Four-Factor Prothrombin Complex Concentrate

Authors :
Aaron D Shmookler
Tracie L Nichols
Peter Perrotta
Source :
American journal of clinical pathology. 156(2)
Publication Year :
2021

Abstract

Objectives The role of transfusion medicine consultative services in prospectively auditing (PA) orders for four-factor prothrombin complex concentrate (4F-PCC) was evaluated at an academic medical center. Methods Data from 4 years of 4F-PCC orders were obtained from the laboratory information system, and electronic health records of patients receiving concentrate were reviewed. Results 4F-PCC was ordered for 427 patients with warfarin-, apixaban-, or rivaroxaban-associated hemorrhage. Turnaround time (TAT) to prepare 4F-PCC was longer when PA-recommended dose adjustments were needed (85 vs 66 minutes, P = .03). There was no difference in TAT between patients who died and those who were ultimately discharged (60 vs 70, P = .22). TAT was shortest for orders originating in the emergency department (ED) compared with other locations (64 vs 85, P Conclusions PA can ensure 4F-PCC is dosed appropriately without affecting patient outcomes.

Details

ISSN :
19437722
Volume :
156
Issue :
2
Database :
OpenAIRE
Journal :
American journal of clinical pathology
Accession number :
edsair.doi.dedup.....d234189d274b825faee15088f0ed53b5