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A Tertiary Academic Medical Center Blood Bank's Experience With Four-Factor Prothrombin Complex Concentrate
- Source :
- American journal of clinical pathology. 156(2)
- Publication Year :
- 2021
-
Abstract
- Objectives The role of transfusion medicine consultative services in prospectively auditing (PA) orders for four-factor prothrombin complex concentrate (4F-PCC) was evaluated at an academic medical center. Methods Data from 4 years of 4F-PCC orders were obtained from the laboratory information system, and electronic health records of patients receiving concentrate were reviewed. Results 4F-PCC was ordered for 427 patients with warfarin-, apixaban-, or rivaroxaban-associated hemorrhage. Turnaround time (TAT) to prepare 4F-PCC was longer when PA-recommended dose adjustments were needed (85 vs 66 minutes, P = .03). There was no difference in TAT between patients who died and those who were ultimately discharged (60 vs 70, P = .22). TAT was shortest for orders originating in the emergency department (ED) compared with other locations (64 vs 85, P Conclusions PA can ensure 4F-PCC is dosed appropriately without affecting patient outcomes.
- Subjects :
- medicine.medical_specialty
Rivaroxaban
Pathology, Clinical
business.industry
Warfarin
Transfusion medicine
Pharmacy
Hemorrhage
General Medicine
Emergency department
030204 cardiovascular system & hematology
Prothrombin complex concentrate
Blood Coagulation Factors
Tertiary Care Centers
03 medical and health sciences
0302 clinical medicine
Emergency medicine
medicine
Blood Banks
Humans
Apixaban
030212 general & internal medicine
business
Blood bank
medicine.drug
Subjects
Details
- ISSN :
- 19437722
- Volume :
- 156
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- American journal of clinical pathology
- Accession number :
- edsair.doi.dedup.....d234189d274b825faee15088f0ed53b5