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Serial proton MR spectroscopy and diffusion tensor imaging in infantile Balo’s concentric sclerosis
- Source :
- Neuroradiology
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Introduction Proton magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) yield different parameters for characterizing the evolution of a demyelinating white matter disease. The purpose was to elucidate biochemical and microstructural changes in Balo’s concentric sclerosis lesions and to correlate the findings with the clinical course. Methods Localized short-echo time MRS and DTI were performed over 6 years in a left occipital lesion of a female patient (age at onset 13.8 years) with Balo’s concentric sclerosis. A right homonym hemianopsia persisted. Results Metabolite patterns were in line with initial active demyelination followed by gliosis and partial recovery of neuroaxonal metabolites. Fractional anisotropy and mean diffusivity of tissue water remained severely altered. Fiber tracking confirmed a disruption in the geniculo-calcarine tract as well as involvement of the corpus callosum. Conclusion MRS and DTI depict complementary parameters, but DTI seems to correlate better with clinical symptoms.
- Subjects :
- Magnetic Resonance Spectroscopy
Adolescent
Clinical Neurology
Corpus callosum
Balo’s concentric sclerosis
White matter
Nuclear magnetic resonance
Fractional anisotropy
medicine
Humans
Tissue Distribution
Radiology, Nuclear Medicine and imaging
Hemianopsia
Neuroradiology
medicine.diagnostic_test
business.industry
Brain
Diffuse Cerebral Sclerosis of Schilder
Magnetic resonance imaging
medicine.disease
Childhood
Magnetic Resonance Imaging
Diffusion tensor imaging
medicine.anatomical_structure
tNAA recovery
nervous system
Gliosis
Radiology Nuclear Medicine and imaging
Female
Neurology (clinical)
Erratum
Paediatric Neuroradiology
Protons
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Diffusion MRI
Subjects
Details
- ISSN :
- 14321920 and 00283940
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Neuroradiology
- Accession number :
- edsair.doi.dedup.....d225635deebdaef8ccbf9e903b99348f