Back to Search
Start Over
Paget's disease of bone: an osteoimmunological disorder?
- Source :
- Drug Design, Development and Therapy
- Publication Year :
- 2015
-
Abstract
- Osteoimmunology represents a large area of research resulting from the cross talk between bone and immune systems. Many cytokines and signaling cascades are involved in the field of osteoimmunology, originating from various cell types. The RANK/receptor activator of nuclear factor Kappa-B ligand (RANKL)/osteoprotegerin (OPG) signaling has a pivotal role in osteoimmunology, in addition to proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1, IL-6, and IL-17. Clinically, osteoimmunological disorders, such as rheumatoid arthritis, osteoporosis, and periodontitis, should be classified according to their pattern of osteoimmunological serum biomarkers. Paget’s disease of bone is a common metabolic bone disorder, resulting from an excessively increased bone resorption coupled with aberrant bone formation. With the exception of the cellular responses to measles virus nucleocapsid protein and the interferon-gamma signature, the exact role of the immune system in Paget’s disease of bone is not well understood. The cytokine profiles, such as the increased levels of IL-6 and the interferon-gamma signature observed in this disease, are also very similar to those observed in other osteoimmunological disorders. As a potential osteoimmunological disorder, the treatment of Paget’s disease of bone may also benefit from progress made in targeted therapies, in particular for receptor activator of nuclear factor Kappa-B ligand and IL-6 signaling inhibition.
- Subjects :
- musculoskeletal diseases
Osteoimmunology
Osteoporosis
SQSTM1/p62
Pharmaceutical Science
Review
Bone and Bones
Bone remodeling
Osteoprotegerin
Osteoclast
Drug Discovery
Medicine
Animals
Humans
Immunologic Factors
Molecular Targeted Therapy
Pharmacology
osteoimmunology
biology
business.industry
RANKL
Paget’s disease of bone
medicine.disease
Osteitis Deformans
Prognosis
3. Good health
Metabolic Bone Disorder
Paget's disease of bone
medicine.anatomical_structure
Immunology
osteoclast
biology.protein
Cytokines
Bone Remodeling
Inflammation Mediators
business
Biomarkers
Signal Transduction
Subjects
Details
- ISSN :
- 11778881
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Drug design, development and therapy
- Accession number :
- edsair.doi.dedup.....d22368c76d18c0a493491719fe2ec4b7