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Statin Use and Skin Cancer Risk: A Prospective Cohort Study
- Source :
- Journal of Investigative Dermatology, Journal of Investigative Dermatology, 2022, 142 (5), pp.1318-1325.e5. ⟨10.1016/j.jid.2021.10.010⟩
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- International audience; Epidemiological studies on statin use in relation to skin cancer risk are scarce and yielded conflicting results. We explored this association in Etude Epidémiologique auprès de femmes de l'Education Nationale, a prospective cohort of French women born in 1925–1950. Health and lifestyle data were self-reported biennially and matched with drug reimbursement data, allowing the identification of participants’ statin use since 2004. Multivariable cause-specific hazards regression models adjusted for skin cancer risk factors estimated hazard ratios with 95% confidence intervals. Over 2004–2014, 455 cutaneous melanoma, 1,741 basal cell carcinoma, and 268 squamous cell carcinoma cases were ascertained among 62,473 women. Compared with never use, there were no associations between ever use of statins and melanoma (hazard ratio = 1.16, 95% confidence interval = 0.94–1.44) or squamous cell carcinoma (hazard ratio = 0.89, 95% confidence interval = 0.66–1.19) risks and a decrease in basal cell carcinoma risk with ever use of statins (hazard ratio = 0.89, 95% confidence interval = 0.79–0.996). We found no trend of increasing or decreasing risks with dose, duration of use, time since first use, or age at first use and no statistically significant effect modification by pigmentary traits or residential UVR exposure. Because of the limited number of studies evaluating the associations between the use of statins and the risks of melanoma, basal cell carcinoma, and squamous cell carcinoma, these findings would deserve further investigation in other settings.
- Subjects :
- Male
medicine.medical_specialty
Skin Neoplasms
[SDV]Life Sciences [q-bio]
[SDV.CAN]Life Sciences [q-bio]/Cancer
Dermatology
Biochemistry
Cohort Studies
[SDV.CAN] Life Sciences [q-bio]/Cancer
Risk Factors
Internal medicine
Epidemiology
medicine
Humans
Basal cell carcinoma
Prospective Studies
Prospective cohort study
Melanoma
Molecular Biology
Proportional Hazards Models
Aged, 80 and over
business.industry
Hazard ratio
Cell Biology
[SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology
medicine.disease
Confidence interval
[SDV] Life Sciences [q-bio]
Defined daily dose
Carcinoma, Basal Cell
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Carcinoma, Squamous Cell
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Skin cancer
business
Body mass index
[SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Subjects
Details
- ISSN :
- 0022202X and 15231747
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Journal of Investigative Dermatology
- Accession number :
- edsair.doi.dedup.....d22222fef8bed6212d76055531d3ff16