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Mutual influence of incorporated drugs in a dual drug delivery coating for cardiovascular applications

Mutual influence of incorporated drugs in a dual drug delivery coating for cardiovascular applications

Authors :
Thomas Eickner
Michael Teske
Katharina Wulf
Claudia Matschegewski
Daniela Arbeiter
Niels Grabow
Klaus-Peter Schmitz
Source :
Current Directions in Biomedical Engineering, Vol 3, Iss 2, Pp 379-382 (2017)
Publication Year :
2017
Publisher :
Walter de Gruyter GmbH, 2017.

Abstract

For a long-term efficient drug-eluting stent for vascular applications, the development of drug-loaded coating, combining the effective inhibition of smooth muscle cell proliferation while promoting the re-endothelialization, is a promising concept. However the mostly required simultaneous incorporation of drugs can influence decisively the stability, efficacy and release of the respective drug. Therefore, the mutual influence of a dual local drug delivery coatings based on poly(L-lactide-co-ε-caprolactone) (PLLA-co-CL) containing vascular endothelial growth factor (VEGF165) coupled to the surface and an embedded drug, such as fluorescein diacetate (FDAc) instead of Paclitaxel (PTX) on the in vitro drug release was investigated. Surprisingly, for the investigated coating the immobilized VEGF loading was enhanced and the release profile was accelerated by FDAc incorporation. Even a manifold increase for the in vitro released amounts of VEGF was detected. In contrast, the immobilization of VEGF seems to have a negligible influence on the in vitro FDAc release profiles.

Details

ISSN :
23645504
Volume :
3
Database :
OpenAIRE
Journal :
Current Directions in Biomedical Engineering
Accession number :
edsair.doi.dedup.....d21a820f33364ec0c1cbb7406c997805
Full Text :
https://doi.org/10.1515/cdbme-2017-0079