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Endothelial Dysfunction in Childhood Cancer Survivors: A Narrative Review
- Source :
- Life, Vol 12, Iss 45, p 45 (2022), Life
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Assessment of endothelial dysfunction in cancer survivors may have a role in the early identification of non-communicable diseases and cardiovascular late effects. Oncological therapies may impair endothelial function. Therefore, in patients such as childhood cancer survivors who could benefit from early cardioprotective pharmacological interventions, it is essential to monitor endothelial function, even if the optimal methodology for investigating the multifaceted aspects of endothelial dysfunction is still under debate. Biochemical markers, as well as invasive and non-invasive tools with and without pharmacological stimuli have been studied. Human clinical studies that have examined lifestyle or cancer treatment protocols have yielded evidence showing the involvement of lipid and lipoprotein levels, glycemic control, blood pressure, adiposity, inflammation, and oxidative stress markers on the state of endothelial health and its role as an early indicator of cardiometabolic risk. However, with regards to pharmacological interventions, cautious interpretation of the result attained whilst monitoring the endothelial function is warranted due to methodological limitations and substantial heterogeneity of the results reported in the published studies. In this narrative review, an overview of evidence from human clinical trials examining the effects of cancer therapies on endothelial disease is provided together with a discussion of endothelial function assessment using the different non-invasive techniques available for researchers and clinicians, in recent years.
- Subjects :
- vascular toxicity
Atherosclerosis
Cancer survivors
Cardiotoxicity
Carotid intima media thickness
Endothelial dysfunction
Flow mediated dilation
Noncommunicable diseases prevention
Peripheral artery tonometry
Pulse wave velocity
Vascular toxicity
pulse wave velocity
Science
cardiotoxicity
Paleontology
Review
noncommunicable diseases prevention
General Biochemistry, Genetics and Molecular Biology
endothelial dysfunction
Space and Planetary Science
peripheral artery tonometry
cancer survivors
carotid intima media thickness
atherosclerosis
Ecology, Evolution, Behavior and Systematics
flow mediated dilation
Subjects
Details
- Language :
- English
- ISSN :
- 20751729
- Volume :
- 12
- Issue :
- 45
- Database :
- OpenAIRE
- Journal :
- Life
- Accession number :
- edsair.doi.dedup.....d2190fa80e29ea5431e556338cf523d5