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Endothelial Dysfunction in Childhood Cancer Survivors: A Narrative Review

Authors :
Marco Crocco
Giuseppe d’Annunzio
Alberto La Valle
Gianluca Piccolo
Decimo Silvio Chiarenza
Carolina Bigatti
Marta Molteni
Claudia Milanaccio
Maria Luisa Garrè
Natascia Di Iorgi
Mohamad Maghnie
Source :
Life, Vol 12, Iss 45, p 45 (2022), Life
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Assessment of endothelial dysfunction in cancer survivors may have a role in the early identification of non-communicable diseases and cardiovascular late effects. Oncological therapies may impair endothelial function. Therefore, in patients such as childhood cancer survivors who could benefit from early cardioprotective pharmacological interventions, it is essential to monitor endothelial function, even if the optimal methodology for investigating the multifaceted aspects of endothelial dysfunction is still under debate. Biochemical markers, as well as invasive and non-invasive tools with and without pharmacological stimuli have been studied. Human clinical studies that have examined lifestyle or cancer treatment protocols have yielded evidence showing the involvement of lipid and lipoprotein levels, glycemic control, blood pressure, adiposity, inflammation, and oxidative stress markers on the state of endothelial health and its role as an early indicator of cardiometabolic risk. However, with regards to pharmacological interventions, cautious interpretation of the result attained whilst monitoring the endothelial function is warranted due to methodological limitations and substantial heterogeneity of the results reported in the published studies. In this narrative review, an overview of evidence from human clinical trials examining the effects of cancer therapies on endothelial disease is provided together with a discussion of endothelial function assessment using the different non-invasive techniques available for researchers and clinicians, in recent years.

Details

Language :
English
ISSN :
20751729
Volume :
12
Issue :
45
Database :
OpenAIRE
Journal :
Life
Accession number :
edsair.doi.dedup.....d2190fa80e29ea5431e556338cf523d5