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Outcome of coronary lesions with deferred revascularization due to negative fractional flow reserve in subjects with acute coronary syndrome
- Source :
- International Journal of Cardiology. 230:335-338
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Objective Revascularization of functionally non-significant stenoses in patients with stable coronary artery disease can safely be deferred as rate of adverse cardiovascular events is low. It is not clear whether fractional flow reserve (FFR) is just as accurate in acute coronary syndromes (ACS). The aim of this study is to assess the outcome of coronary lesions whose revascularization was deferred based on negative FFR values in subjects with ACS. Methods Patients with acute coronary syndrome and showing at least one coronary stenosis whose revascularization was deferred based on FFR value >0.80 were included in the study. The primary endpoint of the study was the rate of target lesion failure (TLF), a composite of cardiac events (cardiac death, myocardial infarction and any coronary revascularization) related to the initially deferred stenosis at three-year follow-up. Results A total of 319 patients (237 male), mean age 68 [59–74] years and 355 coronary lesions with deferred revascularization based on negative FFR values (0.88±0.05) were selected. The rate of TLF was 6% at 1-year, 9% at 2-year and 12% at 3-year follow-up. TLF was driven by a new acute coronary syndrome in 75% of cases. The median time interval from FFR assessment to TLF was 457 [138–868] days. Conclusions In patients with acute coronary syndrome, the rate of TLF of the initially deferred coronary stenoses is 12% at 3-year follow-up and TLF occurred because of a new ACS in three quarters of cases.
- Subjects :
- Male
Target lesion
medicine.medical_specialty
Acute coronary syndrome
Time Factors
medicine.medical_treatment
Coronary revascularization
Fractional flow reserve
Acute Coronary Syndrome
Aged
Coronary Angiography
Female
Follow-Up Studies
Fractional Flow Reserve, Myocardial
Humans
Middle Aged
Myocardial Revascularization
Prognosis
Retrospective Studies
Severity of Illness Index
Cardiology and Cardiovascular Medicine
030204 cardiovascular system & hematology
Revascularization
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Clinical endpoint
Myocardial
030212 general & internal medicine
Myocardial infarction
business.industry
medicine.disease
Stenosis
Cardiology
business
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 230
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....d21796b34002726609f16dcf663189ec