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Association between Body Mass Index, Asymmetric Dimethylarginine and Risk of Cardiovascular Events and Mortality in Norwegian Patients with Suspected Stable Angina Pectoris
- Source :
- PLoS ONE, Vol 11, Iss 3, p e0152029 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- BackgroundAsymmetric dimethylarginine (ADMA) is associated with increased risk of atherosclerotic cardiovascular disease and mortality through inhibition of nitrogen oxide (NO) synthesis. As positive correlations between serum concentrations of NO and body mass index (BMI) have been observed, we aimed to explore whether the potential associations between plasma ADMA levels and the risk of acute myocardial infarction (AMI) and mortality were modified by BMI.MethodsMultivariable Cox proportional hazard models were used to estimate the hazard ratios (HR) for AMI, cardiovascular death and all-cause mortality according to baseline plasma ADMA levels in 4122 patients with suspected stable angina pectoris. Analyses were subsequently repeated in patients with BMI below (low BMI) or above (high BMI) median.ResultsA total of 2982 patients (72%) were men. Median (range) age, plasma ADMA level and BMI were 62 (21-88) years, 0.54 (0.10-1.25) μmol/L and 26.3 (18.5-54.3) kg/m2, respectively. During a mean (standard deviation) follow-up time of 4.7 (1.4) years, 337 (8%) patients suffered from an AMI, 300 (7%) died, whereof 165 (55%) due to cardiovascular disease. Each 0.1 μmol/L increment in plasma ADMA level was associated with an increased risk of AMI (HR (95% CI) 1.21 (1.08, 1.35) and cardiovascular death 1.30 (1.13, 1.49) in participants with low BMI only. Interactions were significant for AMI (p = 0.04) and CV death (p = 0.03). BMI did not modify the association between plasma ADMA levels and all-cause mortality.ConclusionPlasma ADMA levels were associated with risk of AMI and cardiovascular death among patients with low BMI only.
- Subjects :
- 0301 basic medicine
Male
Physiology
Myocardial Infarction
Blood Pressure
Coronary Artery Disease
030204 cardiovascular system & hematology
Pathology and Laboratory Medicine
Vascular Medicine
Body Mass Index
Coronary artery disease
Angina
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Risk Factors
Medicine and Health Sciences
Myocardial infarction
Immune Response
Multidisciplinary
Norway
Hazard ratio
Drugs
Hematology
Middle Aged
Body Fluids
Blood
Physiological Parameters
Cardiology
Medicine
Female
Nitrogen Oxides
Anatomy
Research Article
medicine.medical_specialty
Endocrine Disorders
Science
Immunology
Arginine
Blood Plasma
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Angina, Stable
Pharmacology
Inflammation
business.industry
Body Weight
Statins
Biology and Life Sciences
medicine.disease
030104 developmental biology
Blood pressure
chemistry
Metabolic Disorders
Asymmetric dimethylarginine
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d20c9695ca8e7d395f51b42d2ad1ea0a