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A new 4D trajectory-based approach unveils abnormal LV revolution dynamics in hypertrophic cardiomyopathy
- Source :
- PLoS ONE, PLoS ONE, Vol 10, Iss 4, p e0122376 (2015)
- Publication Year :
- 2014
-
Abstract
- The assessment of left ventricular shape changes during cardiac revolution may be a new step in clinical cardiology to ease early diagnosis and treatment. To quantify these changes, only point registration was adopted and neither Generalized Procrustes Analysis nor Principal Component Analysis were applied as we did previously to study a group of healthy subjects. Here, we extend to patients affected by hypertrophic cardiomyopathy the original approach and preliminarily include genotype positive/phenotype negative individuals to explore the potential that incumbent pathology might also be detected. Using 3D Speckle Tracking Echocardiography, we recorded left ventricular shape of 48 healthy subjects, 24 patients affected by hypertrophic cardiomyopathy and 3 genotype positive/phenotype negative individuals. We then applied Generalized Procrustes Analysis and Principal Component Analysis and inter-individual differences were cleaned by Parallel Transport performed on the tangent space, along the horizontal geodesic, between the per-subject consensuses and the grand mean. Endocardial and epicardial layers were evaluated separately, different from many ecocardiographic applications. Under a common Principal Component Analysis, we then evaluated left ventricle morphological changes (at both layers) explained by first Principal Component scores. Trajectories’ shape and orientation were investigated and contrasted. Logistic regression and Receiver Operating Characteristic curves were used to compare these morphometric indicators with traditional 3D Speckle Tracking Echocardiography global parameters. Geometric morphometrics indicators performed better than 3D Speckle Tracking Echocardiography global parameters in recognizing pathology both in systole and diastole. Genotype positive/phenotype negative individuals clustered with patients affected by hypertrophic cardiomyopathy during diastole, suggesting that incumbent pathology may indeed be foreseen by these methods. Left ventricle deformation in patients affected by hypertrophic cardiomyopathy compared to healthy subjects may be assessed by modern shape analysis better than by traditional 3D Speckle Tracking Echocardiography global parameters. Hypertrophic cardiomyopathy pathophysiology was unveiled in a new manner whereby also diastolic phase abnormalities are evident which is more difficult to investigate by traditional ecocardiographic techniques.
- Subjects :
- Adult
Male
medicine.medical_specialty
Genotype
Heart Ventricles
Diastole
Echocardiography, Three-Dimensional
Shape analysis, Geometric Morphometrics
lcsh:Medicine
Speckle tracking echocardiography
Biology
Internal medicine
medicine
Humans
left ventricle
morphometry
hypertrophic cardiomyopathy
Systole
lcsh:Science
Principal Component Analysis
Multidisciplinary
Receiver operating characteristic
lcsh:R
Hypertrophic cardiomyopathy
Generalized Procrustes analysis
Cardiomyopathy, Hypertrophic
Middle Aged
medicine.disease
Healthy Volunteers
medicine.anatomical_structure
Phenotype
ROC Curve
Ventricle
Principal component analysis
Cardiology
lcsh:Q
Female
Endocardium
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....d20aa29424e16a334fb69df5528b4837