What is the role of inflammatory mediators on energy metabolism?

The subclinical and low intensity inflammation, oxidative stress, high calorie and high fat diet patterns are striking features of the obesity. The adipose tissue, through its endocrine function, is associated with the cytokines secretion, such as: IL-4, IL-13, IL-15 and IFN-γ, which trigger metabolic changes and possibly modulate the energy metabolism by modifying the biochemical, anthropometric and body composition parameters. This review summarizes scientific evidences about the relationship between such cytokines and mediators which alter the energy metabolism, predisposing or preventing the obesity.