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Screening for depression in youth with epilepsy: Psychometric analysis of NDDI-E-Y and NDDI-E in a French population
- Source :
- Epilepsybehavior : EB. 98
- Publication Year :
- 2019
-
Abstract
- The objective of this study was to evaluate the Neurological Disorders Depression Inventory-Epilepsy (NDDI-E) for Youth (NDDI-E-Y) for screening for major depressive disorder (MDD) in French youth with epilepsy (YWE), in order to (1) validate this tool in a separate population; (2) determine whether the 12-item NDDI-E-Y affords advantages over the 6-item adult NDDI-E; (3) measure psychometric performance of each item.Youth with epilepsy aged 11-17 years completed a 15-item questionnaire to calculate total scores for NDDI-E-Y (12 items) and NDDI-E (6 items). Gold standard for MDD was Children's Depression Inventory (CDI). Receiver operator characteristic (ROC) analyses for total NDDI-E-Y and NDDI-E scores were compared. Psychometric properties of each item were analyzed for: floor/ceiling effect, item-internal consistency, and ROC curve.Ninety-seven YWE were included; 21.6% had MDD (CDI 15). Correlation was very high between total NDDI-E-Y and NDDI-E scores, and high between NDDI-E-Y and CDI. Cutoff point for the NDDI-E-Y maximizing both sensitivity and specificity was 23 (original study cutoff 32). The ROC analysis of the NDDI-E-Y showed an area under the curve (AUC) 0.967 (95% confidence intervals [CI] 0.909-0.992); (p 0.0001). Sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) were 100% [83.9; 100], 82.9% [72.5; 90.6], 61.8 [43.6; 77.8], and 100% [94.3; 100], respectively. The NDDI-E-Y was not superior to NDDI-E according to pairwise comparison of ROC (p = 0.07). Psychometric analysis revealed marked differences between items. After eliminating items with poorer performance, a 6-item version of the NDDI-E-Y showed sensitivity, specificity, PPV, and NPV of 100% [85.5; 100], 85.5% [75.6; 92.5], 65.6 [46.8; 81.4], and 100% [94.5; 100], respectively. This was significantly better than the adult NDDI-E (p = 0.03) though not NDDI-E-Y (p = 0.07).Significant difference in cutoff indicates that the NDDI-E-Y cannot yet be recommended for widespread screening of MDD in YWE. Discrepancies in psychometric performance between items suggest that further work is needed to examine both validation of the original 12-item NDDI-E-Y and comparison with a shorter version.
- Subjects :
- Male
Psychometrics
Adolescent
Population
behavioral disciplines and activities
Sensitivity and Specificity
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Surveys and Questionnaires
medicine
Cutoff
Humans
Mass Screening
030212 general & internal medicine
education
Child
Psychiatric Status Rating Scales
education.field_of_study
Depressive Disorder
Epilepsy
Receiver operating characteristic
business.industry
Gold standard (test)
medicine.disease
Confidence interval
Neurology
ROC Curve
Area Under Curve
Major depressive disorder
Ceiling effect
Female
Neurology (clinical)
France
business
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- ISSN :
- 15255069
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Epilepsybehavior : EB
- Accession number :
- edsair.doi.dedup.....d1feb873066a55439fa10ade7330b862