Back to Search
Start Over
Environmental determinants of allergy and asthma in early life
- Publication Year :
- 2017
- Publisher :
- The University of North Carolina at Chapel Hill University Libraries, 2017.
-
Abstract
- Allergic disease prevalence has significantly increased in recent decades. Primary prevention efforts are being guided by the study of the exposome, or collective environmental exposures beginning during the prenatal period, to identify modifiable factors that impact allergic disease risk. In this review, we explore the evidence supporting a relationship between key components of the external exposome in the prenatal and early-life periods and their impact on atopy development, focused on microbial, allergen, and air pollution exposures. The abundance and diversity of microbial exposures during the first months and years of life have been linked with risk of allergic sensitization and disease. Indoor environmental allergen exposure during early life may also impact disease development, depending on the allergen type, dose, and timing of exposure. Recent evidence supports the role of ambient air pollution in allergic disease inception. The lack of clarity in the literature surrounding the relationship between environment and atopy reflects the complex interplay between cumulative environmental factors and genetic susceptibility, such that no one factor dictates disease development in all individuals. Understanding the impact of the summation of environmental exposures throughout a child's development is needed to identify cost-effective interventions that reduce atopy risk in children.
- Subjects :
- 0301 basic medicine
Exposome
Allergy
Immunology
Disease
Article
Atopy
Allergic sensitization
03 medical and health sciences
0302 clinical medicine
Risk Factors
Air Pollution
Environmental health
Hypersensitivity
medicine
Animals
Humans
Immunology and Allergy
Asthma
House dust mite
biology
business.industry
Microbiota
Environmental Exposure
Atopic dermatitis
Allergens
medicine.disease
biology.organism_classification
030104 developmental biology
030228 respiratory system
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d1f48bb86f0ff6e91ebfbbed0084cff6
- Full Text :
- https://doi.org/10.17615/0n72-tr19