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Landscape of Noncoding RNA in Prostate Cancer
- Source :
- Trends in genetics : TIG. 35(11)
- Publication Year :
- 2019
-
Abstract
- The transcriptome of prostate cancer is highly heterogeneous, with noncoding transcripts being essential players. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two unique classes of noncoding RNA drawing increasing attention. Biologically, they have intriguing properties with important regulatory functions. Clinically, they present as promising biomarkers and therapeutic targets. Recent advancements in technologies have opened up new directions for noncoding RNA research, which include RNA–protein interaction, RNA secondary structure, and spatial transcriptomics. Furthermore, recent work has also evaluated the clinical applications of these noncoding RNAs in noninvasive liquid biopsy and RNA-based therapies. In this review, we summarize recent findings on lncRNAs and circRNAs in prostate cancer, discuss their clinical utilities, and highlight these exciting areas of research.
- Subjects :
- Male
Computational biology
Biology
Nucleic acid secondary structure
Transcriptome
03 medical and health sciences
Prostate cancer
Structure-Activity Relationship
0302 clinical medicine
Circular RNA
Genetics
medicine
Biomarkers, Tumor
Humans
Genetic Predisposition to Disease
Liquid biopsy
030304 developmental biology
0303 health sciences
Prostatic Neoplasms
RNA-Binding Proteins
RNA, Circular
Non-coding RNA
medicine.disease
Long non-coding RNA
Gene Expression Regulation, Neoplastic
RNA, Long Noncoding
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01689525
- Volume :
- 35
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Trends in genetics : TIG
- Accession number :
- edsair.doi.dedup.....d1f0f266d2f878c7c7e0221f04f44f5f