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Histamine and astrocyte function
- Source :
- Pharmacological Research. 111:774-783
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Astrocytes support the brain through numerous functional interactions in health and disease. The recent advances in our knowledge of astrocyte involvement in various neurological disorders raised up several questions about their role and functioning in the central nervous system. From the evidence discussed in this review, we show that histamine importantly influences the main astrocytic activities such as ion homeostasis, energy metabolism, neurotransmitter clearance, neurotrophic activity and immune response. These processes are mediated through at least three histamine receptor subtypes, H1, H2 and H3, expressed on the astrocyte surface. Thus, we recognize histamine as an important player in the modulation of astrocytic functions that deserves further considerations in exploring involvement of astrocytes in neurological disorders.
- Subjects :
- Central Nervous System
0301 basic medicine
Central nervous system
Histamine H1 receptor
Biology
03 medical and health sciences
chemistry.chemical_compound
Histamine receptor
0302 clinical medicine
Central Nervous System Diseases
medicine
Animals
Homeostasis
Humans
Pharmacology
030104 developmental biology
Ion homeostasis
medicine.anatomical_structure
chemistry
Astrocytes
Immunology
biology.protein
Receptors, Histamine
Histamine H3 receptor
Neuroscience
030217 neurology & neurosurgery
Histamine
Signal Transduction
Astrocyte
Neurotrophin
Subjects
Details
- ISSN :
- 10436618
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Pharmacological Research
- Accession number :
- edsair.doi.dedup.....d1eb784ba0bf2e5eaa6a56a7ecd5aa1c