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Depression, quality of life, and body composition in patients with end-stage renal disease: a cohort study
- Source :
- Brazilian Journal of Psychiatry v.38 n.4 2016, Brazilian Journal of Psychiatry (São Paulo. 1999. Online), Associação Brasileira de Psiquiatria (ABP), instacron:ABP, Brazilian Journal of Psychiatry, Revista Brasileira de Psiquiatria, Volume: 38, Issue: 4, Pages: 301-306, Published: 05 FEB 2016, Brazilian Journal of Psychiatry, Iss 0 (2016)
- Publication Year :
- 2016
- Publisher :
- Associação Brasileira de Psiquiatria, 2016.
-
Abstract
- Objective: To prospectively evaluate depressive symptoms, nutritional status, and quality of life (QoL) and search for possible associations in patients with end-stage renal disease undergoing hemodialysis. Methods: A cohort study of 104 adult patients with end-stage renal disease undergoing hemodialysis was conducted. Anthropometric, clinical, and biochemical variables were evaluated after a midweek hemodialysis session. The participants’ body composition was assessed by direct segmental multi-frequency bioimpedance analysis. The WHOQOL-Bref questionnaire was used to evaluate QoL. Participants were separated into two groups - depressive symptoms and no depressive symptoms - at inclusion and evaluated annually for 2 years thereafter using the Beck Depression Inventory. Survival analysis used the Kaplan-Meier method and Cox regression analysis for the goodness of fit of associated factors. All-cause mortality was the outcome of interest. Results: Participants’ mean age was 55.3±15.6 years, 60% were male, and the median time on hemodialysis was 17.5 (8.0-36.8) months. Thirty-two patients had depressive symptoms and a significantly lower QoL compared with the 72 patients in the no depressive symptoms group. The fitted outcome model showed that lean body mass had a protective effect against all-cause mortality (hazard ratio [HR] = 0.89; 95%CI 0.80-0.99; p = 0.038). Conclusion: Depressive symptoms were highly prevalent in the cohort, and correlated with the physical and psychological components of the QoL life questionnaire, as well as with C-reactive protein and phosphorus levels. Lean body mass was protective for the assessed outcome.
- Subjects :
- Gerontology
Adult
Male
medicine.medical_specialty
lcsh:RC435-571
medicine.medical_treatment
030232 urology & nephrology
Nutritional Status
Body composition
End stage renal disease
03 medical and health sciences
0302 clinical medicine
Quality of life
Renal Dialysis
Internal medicine
lcsh:Psychiatry
medicine
Humans
030212 general & internal medicine
Prospective Studies
Aged
hemodialysis
business.industry
Depression
Hazard ratio
Beck Depression Inventory
Middle Aged
mortality
Psychiatry and Mental health
quality of life
Cohort
depression
Lean body mass
Kidney Failure, Chronic
Original Article
Female
Hemodialysis
business
Cohort study
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Brazilian Journal of Psychiatry v.38 n.4 2016, Brazilian Journal of Psychiatry (São Paulo. 1999. Online), Associação Brasileira de Psiquiatria (ABP), instacron:ABP, Brazilian Journal of Psychiatry, Revista Brasileira de Psiquiatria, Volume: 38, Issue: 4, Pages: 301-306, Published: 05 FEB 2016, Brazilian Journal of Psychiatry, Iss 0 (2016)
- Accession number :
- edsair.doi.dedup.....d1e549a0f6f9cd70bd0c489d641d8f5f